Os efeitos da cannabis no sono: uma revisão narrativa

Abstract

Sleep disturbances are prevalent and associated with significant health and socioeconomic impacts. Interest in cannabinoids for sleep disorder therapy has grown due to their potential therapeutic properties, notably those of delta-9-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD). This review evaluates existing clinical evidence regarding cannabinoids' efficacy and safety in treating sleep disorders, including insomnia, obstructive sleep apnea, restless legs syndrome, and REM sleep behavior disorder. While cannabinoids exhibit promising therapeutic effects, studies report variable outcomes and methodological diversity. Clinical trials suggest potential benefits, such as improved sleep quality and reduced sleep-onset latency; however, these findings often derive from limited samples and short-term studies. Reported adverse effects include dizziness and headache, necessitating cautious use. Given increasing global medicinal cannabis access and variability in product quality, rigorous randomized controlled trials and standardized guidelines are essential to clarify cannabinoids' therapeutic potential and safety profile for clinical management of sleep disorders.