A comparative morphometric analysis of orbital anatomy in meningioma-related greater sphenoid wing hyperostosis

Abstract

Introduction: Hiperostosing meningiomas are frequently found in compromising locations, making their surgical resection even more challenging and associated with important comorbidities. A morphometrical analysis of the orbital anatomy and its associated changes could be very beneficial to future research, prognosis, and classification of meningiomas, ultimately leading to better clinical outcomes. Methods: An observational retrospective cohort from a single-center was performed, including patients with "en-plaque" or hiperostosing meningioma cases affecting the orbit with available pre-operative imaging data. Biometrical data was collected, and bilateral data, including Bony volume (VO), Soft tissue volume (VS), Optic canal cross sectional area at the optic strut level (CO), Superior orbital fissure area (FOS), Intraorbitary optic nerve length (ONL), Intraorbitary meningioma volume (IOV) and Greater sphenoid wing volume (VGSW) were collected. Results: A total of 20 hyperostotic meningioma of the sphenoid wing cases were analysed in the end, which 18 (90%) were female and 2 (10%) were male study subjects. The mean age of the selected patients was 54,75 years, ranging from 33 to 88 years old. There was no significant difference in the laterality of the meningiomas. Conclusion: The results obtained further validate the current knowledge of the matter but need additional data to strengthen them. Hyperostosing meningiomas affecting the orbit are, however, relatively rare. This study also shows the very complex nature of these tumoral subtypes and subsequent necessity of preoperative planning.