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Author(s): Gonçalo Pereira Espínola
Title: "Breast Implant - Associated Anaplastic Large Cell Lymphoma (BIA- ALCL)" - Etiopatogenese
Issue Date: 2023-09-15
Abstract: BIA-ALCL is a non-Hodgkin's T cell lymphoma and anaplastic lymphoma Kinase negative (ALK-) firstly described by Keech Jr in 1997 and recognised as a new disease in 2016 by World Health Organization. There are above all three major factors leading to the development of BIA-ALCL laying on genetic background, bacterial contamination and chronic inflammation. Most of the cases have been reported in the context of textured breast implants, which can lead the scientific community to speculate about the etiphatogenesis. Herein, we intend to scrutinize the existing literature about BIA-ALCL etiopathogenesis and explore some mechanisms to choose the best type of implant and procedures to reduce this disease morbidity.
Description: Breast Implant - associated Anaplastic Large Cell Lymphoma (BIA-ALCL) is a relatively recent entity and, since 2009, its prevalence has been rising catching the attention of the scientific community with the main goal of understanding this lymphoproliferative pathology at different levels. The marked increase in the number of cases has raised several hypotheses surrounding the BIA-ALCL pathogenesis; although any of them, aren´t totally accepted or confirmed there are a few theories that worth further investigation and can lead to a better comprehension and prevention of this outcome.
Subject: Medicina clínica
Clinical medicine
Scientific areas: Ciências médicas e da saúde::Medicina clínica
Medical and Health sciences::Clinical medicine
Document Type: Dissertação
Rights: openAccess
Appears in Collections:FMUP - Dissertação

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