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https://hdl.handle.net/10216/151800| Author(s): | Afonso Nóbrega Rodrigues |
| Title: | Pharmacokinetic and Toxicological Aspects of 1,3-dimethylamilamine with Clinical and Forensic Impact |
| Issue Date: | 2023-05-26 |
| Abstract: | 1,3-dimethylamylamine (1,3-DMAA) is a simple straight chain aliphatic sympathomimetic amine, which was used as a nasal decongestant between 1948 and 1983. It reappeared both in dietary supplements as a substitute for ephedrine, and in party pills as an alternative to 3,4-methylenedioxymethamphetamine and/or 1-benzylpiperazine, after these substances were banned. Following its introduction to the market it became one of the most widespread used stimulants, and several case reports started to raise concerns about the safety and adverse effects of 1,3-DMAA. As a result, many countries banned or restricted the sale of 1,3-DMAA. Nevertheless, and despite the efforts of regulating agencies it has been reported that 1,3-DMAA is still found in dietary supplements and has been identified in doping controls. Therefore, the objective of this work is to review of both clinical and forensic aspects of 1,3-DMAA. |
| Description: | A 1,3-dimetilamilamina (1,3-DMAA) é uma amina simpaticomimética alifática simples de cadeia linear, que foi utilizada como descongestionante nasal entre 1948 e 1983. Reapareceu tanto em suplementos dietéticos como substituto da efedrina, quanto em comprimidos para festas como uma alternativa à 3,4-metilenodioximetanfetamina e/ou 1-benzilpiperazina, depois destas substâncias terem sido proibidas. Após a sua introdução no mercado, tornou-se um dos estimulantes mais difundidos, e vários relatos de casos começaram a levantar preocupações sobre a segurança e os efeitos adversos do 1,3-DMAA. Como resultado, muitos países proibiram ou restringiram a venda de 1,3-DMAA. No entanto, e apesar dos esforços das agências reguladoras, foi relatado que o 1,3-DMAA ainda é encontrado em suplementos dietéticos e foi identificado em controlos de doping. Portanto, o objetivo deste trabalho é rever os aspectos clínicos e forenses do 1,3-DMAA. |
| Subject: | Medicina básica Basic medicine |
| Scientific areas: | Ciências médicas e da saúde::Medicina básica Medical and Health sciences::Basic medicine |
| DOI: | 10.34626/zb1x-2j46 |
| TID identifier: | 203520017 |
| URI: | https://hdl.handle.net/10216/151800 |
| Document Type: | Dissertação |
| Rights: | restrictedAccess |
| License: | https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Appears in Collections: | FMUP - Dissertação |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 636047.pdf Restricted Access | Pharmacokinetic and Toxicological Aspects of 1,3-dimethylamilamine with Clinical and Forensic Impact | 4.47 MB | Adobe PDF | View/Open |
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