Please use this identifier to cite or link to this item:
Author(s): Martins, C
Vidal, A
De Boevre, M
De Saeger, S
Nunes, C
Torres, Duarte
Goios, A
Lopes, C
Alvito, P
Assunção, R
Title: Burden of disease attributable to exposure to aflatoxins in Portugal using Human biomonitoring data
Issue Date: 2019
Abstract: <jats:title>Abstract</jats:title> <jats:sec> <jats:title /> <jats:p>Human biomonitoring (HBM) is recognized as an important tool to assess the Human exposure to chemicals, contributing to describe trends and patterns of exposure over time and to identify population groups that could be under risk. Natural chemicals as mycotoxins, fungi metabolites that produce toxic effects in humans, are important compounds that could be found in foods usually consumed worldwide in a daily basis. Mycotoxins as aflatoxins (AFTs) are genotoxic, carcinogenic and immunosuppressive compounds. Hepatocellular carcinoma (HCC) is one of their main health toxic effects and is the third leading cause of cancer deaths worldwide. In Portugal, scarce data are available regarding exposure to AFTs and none previous study used HBM data to characterize comprehensively the burden associated to this exposure.</jats:p> <jats:p>In the scope of the National Food, Nutrition, and Physical Activity Survey of the Portuguese General Population (2015-2016), 24h-urine samples from 94 participants were analyzed by liquid chromatography-mass spectrometry (LC-MS/MS) for the simultaneous determination of AFTs (B1, B2, G1, G2, M1). A model was developed to estimate the health impact of the exposure of Portuguese population to aflatoxins, estimating the number of cases of HCC and DALYs attributed to AFTs exposure.</jats:p> <jats:p>AFTs were detected in 12.8% (AFB1), 16.0% (AFB2) and 19.1% (AFM1) of the 24h-urine samples. The estimated number of extra cases of HCC attributed to this exposure ranged from 17 to 65 cases/year; the associated DALYs for the Portuguese population ranged from 284 to 1802 years.</jats:p> <jats:p>The present study generated, for the first time and within a HBM study, reliable data regarding the exposure of the Portuguese population to AFTs. These data were crucial to characterize the health impact associated to AFTs exposure and to support risk managers to establish preventive policy measures that contribute to ensure the public health protection.</jats:p> </jats:sec> <jats:sec> <jats:title>Key messages</jats:title> <jats:p>Portuguese population is exposed to aflatoxins, chemical food contaminants that may be harmful (carcinogenic, immunotoxic, mutagenic, teratogenic, hepatotoxic) to humans. Human biomonitoring studies provide realistic data on internal exposure at individual level, contributing to a more accurate estimation of the burden derived from this exposure.</jats:p> </jats:sec>
Subject: Ciências da Saúde, Ciências médicas e da saúde
Health sciences, Medical and Health sciences
Scientific areas: Ciências médicas e da saúde
Medical and Health sciences
Source: European Journal of Public Health. 2019; Vol.29, n.º 4 (12th European Public Health Conference abstracts)
Document Type: Resumo de Comunicação em Conferência Internacional
Rights: restrictedAccess
Appears in Collections:FCNAUP - Resumo de Comunicação em Conferência Internacional

Files in This Item:
File Description SizeFormat 
  Restricted Access
71.03 kBAdobe PDF    Request a copy from the Author(s)

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.