Please use this identifier to cite or link to this item: https://hdl.handle.net/10216/130567
Author(s): Beckmann, M
Lloyd, AJ
Wilson, T
Torres, Duarte
Goios, ACL
Willis, ND
Lyons, L
Phillips, H
Mathers, JC
Nash, RJ
Sharp, H
Draper, J
Title: Calystegines are Potential Urine Biomarkers for Dietary Exposure to Potato Products
Issue Date: 2020
Abstract: Scope Metabolites derived from specific foods present in urine samples can provide objective biomarkers of food intake (BFIs). This study investigated the possibility that calystegines (a class of iminosugars) may provide BIFs for potato (Solanum tuberosumL.) product exposure. Methods and results Calystegine content is examined in published data covering a wide range of potato cultivars. Rapid methods are developed for the quantification of calystegines in cooked potato products and human urine using triple quadrupole mass spectrometry. The potential of calystegines as BFIs for potato consumption is assessed in a controlled food intervention study in the United Kingdom and validated in an epidemiological study in Portugal. Calystegine concentrations are reproducibly above the quantification limit in first morning void urines the day after potato consumption, showing a good dose-response relationship, particularly for calystegine A(3). The design of the controlled intervention mimicks exposure to a typical UK diet and showed that neither differences in preparation/cooking method or influence of other foods in the diet has significant impact on biomarker performance. Calystegine biomarkers also perform well in the independent validation study. Conclusion It is concluded that calystegines have many of the characteristics needed to be considered as specific BFIs for potato product intake.
Subject: Ciências da Saúde, Ciências médicas e da saúde
Health sciences, Medical and Health sciences
Scientific areas: Ciências médicas e da saúde
Medical and Health sciences
URI: https://hdl.handle.net/10216/130567
Document Type: Artigo em Revista Científica Internacional
Rights: restrictedAccess
Appears in Collections:FCNAUP - Artigo em Revista Científica Internacional

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