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https://hdl.handle.net/10216/130163
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DC Field | Value | Language |
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dc.creator | Mourao, J | |
dc.creator | Rebelo, A | |
dc.creator | Ribeiro, S | |
dc.creator | Peixe, L. | |
dc.creator | Novais, Carla | |
dc.creator | Antunes, Patrícia | |
dc.date.accessioned | 2020-11-17T00:18:32Z | - |
dc.date.available | 2020-11-17T00:18:32Z | - |
dc.date.issued | 2020 | |
dc.identifier.issn | 1462-2912 | |
dc.identifier.other | sigarra:400870 | |
dc.identifier.uri | https://hdl.handle.net/10216/130163 | - |
dc.description.abstract | Emergence and expansion of frequent multidrug-resistant (MDR) major Salmonella clones/serotypes has been a significant threat in the last years. Metal compounds, such as copper, commonly used in animal-production settings, have been pointed out as possible contributors for the selection of such strains/clones. However, the scarcity of studies limits our understanding of the impact of other metal environmental contaminants as arsenic (used in insecticides/herbicides/coccidiostats). We analysed arsenic tolerance (AsT) dispersion by phenotypic and genotypic (PCR/sequencing/I-CeuI/S1/XbaI-PFGE/hybridization) assays among Salmonella with diverse epidemiological and genetic backgrounds. Then, to better understand ars operon genetic contexts, the whole genome of five representative strains was sequenced. We found a high dispersion of ars operons conferring AsT, especially among copper-tolerant and relevant serotypes/clones related to pig-production setting. The acr3-type was found dispersed in the chromosome of diverse serotypes, including the emergent S. Rissen. Conversely, arsBII was almost confined to the MDR ST34 European clone of S. Typhimurium/S. 4,[5],12:i:-, always along with copper/silver tolerance sil + pco clusters in an integrative conjugative element. These data suggest that AsT is an essential adaptive feature for the ecological success of these epidemic clones/serotypes and alerts for global strategies to reduce arsenic-based compounds' impact thus preventing environmental/food contamination with frequent MDR foodborne pathogens. | |
dc.language.iso | eng | |
dc.rights | restrictedAccess | |
dc.subject | Ciências da Saúde, Ciências médicas e da saúde | |
dc.subject | Health sciences, Medical and Health sciences | |
dc.title | Tolerance to arsenic contaminant among multidrug-resistant and copper-tolerant Salmonella successful clones is associated with diverse ars operons and genetic contexts | |
dc.type | Artigo em Revista Científica Internacional | |
dc.contributor.uporto | Faculdade de Farmácia | |
dc.contributor.uporto | Faculdade de Ciências da Nutrição e Alimentação | |
dc.identifier.doi | 10.1111/1462-2920.15016 | |
dc.identifier.authenticus | P-00S-YEA | |
dc.subject.fos | Ciências médicas e da saúde | |
dc.subject.fos | Medical and Health sciences | |
Appears in Collections: | FCNAUP - Artigo em Revista Científica Internacional FFUP - Artigo em Revista Científica Internacional |
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File | Description | Size | Format | |
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400870.pdf Restricted Access | 720.34 kB | Adobe PDF | Request a copy from the Author(s) |
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