Please use this identifier to cite or link to this item: https://hdl.handle.net/10216/124947
Author(s): Imran, M
Salehi, B
Sharifi Rad, J
Gondal, TA
Saeed, F
Imran, A
Shahbaz, M
Fokou, PVT
Arshad, MU
Khan, H
Susana Guerreiro
Martins, N
Estevinho, LM
Title: Kaempferol: A Key Emphasis to Its Anticancer Potential
Issue Date: 2019
Abstract: A marked decrease in human cancers, including breast cancer, bone cancer, and cervical cancer, has been linked to the consumption of vegetable and fruit, and the corresponding chemoprotective effect has been associated with the presence of several active molecules, such as kaempferol. Kaempferol is a major flavonoid aglycone found in many natural products, such as beans, bee pollen, broccoli, cabbage, capers, cauliflower, chia seeds, chives, cumin, moringa leaves, endive, fennel, and garlic. Kaempferol displays several pharmacological properties, among them antimicrobial, anti-inflammatory, antioxidant, antitumor, cardioprotective, neuroprotective, and antidiabetic activities, and is being applied in cancer chemotherapy. Specifically, kaempferol-rich food has been linked to a decrease in the risk of developing some types of cancers, including skin, liver, and colon. The mechanisms of action include apoptosis, cell cycle arrest at the G2/M phase, downregulation of epithelial-mesenchymal transition (EMT)-related markers, and phosphoinositide 3-kinase/protein kinase B signaling pathways. In this sense, this article reviews data from experimental studies that investigated the links between kaempferol and kaempferol-rich food intake and cancer prevention. Even though growing evidence supports the use of kaempferol for cancer prevention, further preclinical and clinical investigations using kaempferol or kaempferol-rich foods are of pivotal importance before any public health recommendation or formulation using kaempferol.
Subject: Ciências da Saúde, Ciências médicas e da saúde
Health sciences, Medical and Health sciences
Scientific areas: Ciências médicas e da saúde
Medical and Health sciences
URI: https://hdl.handle.net/10216/124947
Document Type: Outra Publicação em Revista Científica Internacional
Rights: openAccess
Appears in Collections:FCNAUP - Outra Publicação em Revista Científica Internacional

Files in This Item:
File Description SizeFormat 
371989.pdf710.69 kBAdobe PDFThumbnail
View/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.