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dc.creatorViegas, Olga
dc.creatorFaria, MA
dc.creatorSousa, JB
dc.creatorVojtek, M
dc.creatorGoncalves Monteiro, S
dc.creatorSuliburska, J
dc.creatorDiniz, C
dc.creatorFerreira, IMPLVO
dc.description.abstractExcessive angiogenesis favours cancer development, allowing cancer invasion. Polyphenols are promising chemopreventive agents, although data gather so far in respect of anthocyanins, namely cyanidin-3-O-glucoside and delphinidin-3-O-glucoside (DG) and respective aglycones are scarce. The capability of these compounds to prevent tumour progression by inhibiting angiogenesis/cell migration/proliferation was studied in: (i) chicken embryo chorioallantoic membrane assay; (ii) MDA-MB-231/MCF-12A cells to study proliferation and vascular endothelial growth factor receptor-2 (VEGFR-2) expression and cytoskeleton dynamics; (iii) in vitro assay to evaluate gastrointestinal digestion. The studied compounds promoted alterations on actin re/disassembly to form protrusions/stress fibres, evidencing capability to disrupt actin cytoskeleton dynamics and inhibiting angiogenesis, at least in part, by VEGFR-2 downregulation, with DG presenting the higher effect. Anthocyanin evidenced selectivity towards cancer cells by eliciting cytotoxicity on MDA-MB-231 cells and having a slight effect on healthy cells. Thus, DG evidenced the most promising profile as dietary supplement to achieve the biological desired effects.
dc.subjectCiências da Saúde, Ciências médicas e da saúde
dc.subjectHealth sciences, Medical and Health sciences
dc.titleDelphinidin-3-O-glucoside inhibits angiogenesis via VEGFR2 downregulation and migration through actin disruption
dc.typeArtigo em Revista Científica Internacional
dc.contributor.uportoFaculdade de Ciências da Nutrição e Alimentação
dc.subject.fosCiências médicas e da saúde
dc.subject.fosMedical and Health sciences
Appears in Collections:FCNAUP - Artigo em Revista Científica Internacional

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