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https://hdl.handle.net/10216/118213| Author(s): | Freitas-Junior, JCM Andrade-da-Costa, J Silva, M Pinho, SS |
| Title: | Glycans as regulatory elements of the insulin/IGF system: Impact in cancer progression |
| Publisher: | MDPI |
| Issue Date: | 2017 |
| Abstract: | The insulin/insulin-like growth factor (IGF) system in mammals comprises a dynamic network of proteins that modulate several biological processes such as development, cell growth, metabolism, and aging. Dysregulation of the insulin/IGF system has major implications for several pathological conditions such as diabetes and cancer. Metabolic changes also culminate in aberrant glycosylation, which has been highlighted as a hallmark of cancer. Changes in glycosylation regulate every pathophysiological step of cancer progression including tumour cell-cell dissociation, cell migration, cell signaling and metastasis. This review discusses how the insulin/IGF system integrates with glycosylation alterations and impacts on cell behaviour, metabolism and drug resistance in cancer. |
| Subject: | Animals Glycosylation Humans Insulin/genetics Insulin/metabolism Insulin-Like Growth Factor I/genetics Insulin-Like Growth Factor I/metabolism Neoplasms/genetics Neoplasms/metabolism Neoplasms/pathology Polysaccharides/metabolism Regulatory Sequences, Nucleic Acid/genetics Signal Transduction/genetics Signal Transduction/physiology |
| URI: | https://repositorio-aberto.up.pt/handle/10216/118213 |
| Source: | International Journal of Molecular Sciences, vol.18(9). pii: E1921 |
| Document Type: | Artigo em Revista Científica Internacional |
| Rights: | openAccess |
| License: | https://creativecommons.org/licenses/by/4.0/ |
| Appears in Collections: | I3S - Artigo em Revista Científica Internacional |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| INT J MOL SCIENCES 2017.pdf | 1.21 MB | Adobe PDF |  View/Open |
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