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Author(s): Freitas-junior, J
Andrade-da-Costa, J
Silva, M
Pinho, SS
Title: Glycans as regulatory elements of the insulin/IGF system: Impact in cancer progression
Publisher: MDPI
Issue Date: 2017
Abstract: The insulin/insulin-like growth factor (IGF) system in mammals comprises a dynamic network of proteins that modulate several biological processes such as development, cell growth, metabolism, and aging. Dysregulation of the insulin/IGF system has major implications for several pathological conditions such as diabetes and cancer. Metabolic changes also culminate in aberrant glycosylation, which has been highlighted as a hallmark of cancer. Changes in glycosylation regulate every pathophysiological step of cancer progression including tumour cell-cell dissociation, cell migration, cell signaling and metastasis. This review discusses how the insulin/IGF system integrates with glycosylation alterations and impacts on cell behaviour, metabolism and drug resistance in cancer.
Subject: Animals
Insulin-Like Growth Factor I/genetics
Insulin-Like Growth Factor I/metabolism
Regulatory Sequences, Nucleic Acid/genetics
Signal Transduction/genetics
Signal Transduction/physiology
Source: International Journal of Molecular Sciences, vol.18(9). pii: E1921
Document Type: Artigo em Revista Científica Internacional
Rights: openAccess
Appears in Collections:I3S - Artigo em Revista Científica Internacional

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