1. Repositório Aberto da Universidade do Porto
  2. I3S - Instituto de Investigação e Inovação em Saúde
  3. I3S - Artigo em Revista Científica Internacional
Please use this identifier to cite or link to this item: https://hdl.handle.net/10216/118213
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dc.creatorFreitas-Junior, JCM-
dc.creatorAndrade-da-Costa, J-
dc.creatorSilva, M-
dc.creatorPinho, SS-
dc.date.accessioned2019-01-08T17:30:03Z-
dc.date.available2019-01-08T17:30:03Z-
dc.date.issued2017-
dc.identifier.issn1661-6596-
dc.identifier.urihttps://repositorio-aberto.up.pt/handle/10216/118213-
dc.description.abstractThe insulin/insulin-like growth factor (IGF) system in mammals comprises a dynamic network of proteins that modulate several biological processes such as development, cell growth, metabolism, and aging. Dysregulation of the insulin/IGF system has major implications for several pathological conditions such as diabetes and cancer. Metabolic changes also culminate in aberrant glycosylation, which has been highlighted as a hallmark of cancer. Changes in glycosylation regulate every pathophysiological step of cancer progression including tumour cell-cell dissociation, cell migration, cell signaling and metastasis. This review discusses how the insulin/IGF system integrates with glycosylation alterations and impacts on cell behaviour, metabolism and drug resistance in cancer.-
dc.description.sponsorshipFinancial support from Portugal: Institute of Molecular Pathology and Immunology of University of Porto (IPATIMUP) integrates the i3S research unit, which is partially supported by the Portuguese Foundation for Science and Technology (FCT). This article is a result of the project NORTE-01-0145-FEDER-000029, supported by the Norte Portugal Regional Programme (NORTE 2020) under the PORTUGAL 2020 Partnership Agreement through the European Regional Development Fund (ERDF). This work was also funded by FEDER—Fundo Europeu de Desenvolvimento Regional funds through the COMPETE 2020—Operacional Programme for Competitiveness and Internationalisation (POCI), Portugal 2020, and by Portuguese funds through FCT—Fundação para a Ciência e a Tecnologia/ Ministério da Ciência, Tecnologia e Inovação in the framework of the project (POCI-01/0145-FEDER-016601). Financial support from Brazil: Ministério da Saúde and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), under the project 336/13.-
dc.language.isoeng-
dc.publisherMDPI-
dc.relation.ispartofInternational Journal of Molecular Sciences, vol.18(9). pii: E1921-
dc.rightsopenAccess-
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/-
dc.subjectAnimals-
dc.subjectGlycosylation-
dc.subjectHumans-
dc.subjectInsulin/genetics-
dc.subjectInsulin/metabolism-
dc.subjectInsulin-Like Growth Factor I/genetics-
dc.subjectInsulin-Like Growth Factor I/metabolism-
dc.subjectNeoplasms/genetics-
dc.subjectNeoplasms/metabolism-
dc.subjectNeoplasms/pathology-
dc.subjectPolysaccharides/metabolism-
dc.subjectRegulatory Sequences, Nucleic Acid/genetics-
dc.subjectSignal Transduction/genetics-
dc.subjectSignal Transduction/physiology-
dc.titleGlycans as regulatory elements of the insulin/IGF system: Impact in cancer progression-
dc.typeArtigo em Revista Científica Internacional-
dc.contributor.uportoInstituto de Investigação e Inovação em Saúde-
dc.identifier.doi10.3390/ijms18091921-
dc.relation.publisherversionhttps://www.mdpi.com/1422-0067/18/9/1921-
Appears in Collections:I3S - Artigo em Revista Científica Internacional

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