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https://hdl.handle.net/10216/103248| Author(s): | Sandra Rocha Maria do Carmo Pereira Manuel A. N. Coelho Sílvia Castro Coelho Petras Juzenas |
| Title: | Functionalized gold nanoparticles for drug delivery |
| Issue Date: | 2013 |
| Abstract: | Gold nanoparticles are versatile vectors for biological applications including in cancer therapy and diagnosis. Combining gold nanoparticles/anticancer drugs with X-rays radiation may contribute to tumor eradication and treatment efficacy. The conjugation of a proteasome inhibitor (BTZ) with functionalized gold nanoparticles were tested. The drug activity and the anticancer effects in human prostate cancer cells (Du-145) were evaluated. It was observed that gold nanoparticles, with small diameters (24 nm), at concentrations of 0.1 nM are not toxic for Du-145 cells. Finally, nanoparticle parameters were discussed and new ideas are proposed to optimize the anticancer properties of conjugated gold nanoparticles leading to a better delivery of the drug, minimizing the side effects. |
| Subject: | Biotecnologia ambiental Environmental biotechnology |
| Scientific areas: | Ciências da engenharia e tecnologias::Biotecnologia ambiental Engineering and technology::Environmental biotechnology |
| URI: | https://hdl.handle.net/10216/103248 |
| Source: | 3rd Portuguese Bioengineering Meeting, ENBENG 2013 - Book of Proceedings |
| Related Information: | info:eu-repo/grantAgreement/FCT - Fundação para a Ciência e a Tecnologia/Projectos de I&DT em Todos os Domínios Científicos/PTDC/QUI-BIQ/115449/2009/Distibuição de biomoleculas através de nanopartículas inorganica/organicas /BIONANO |
| Document Type: | Artigo em Livro de Atas de Conferência Internacional |
| Rights: | restrictedAccess |
| Appears in Collections: | FEUP - Artigo em Livro de Atas de Conferência Internacional |
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|---|---|---|---|---|
| 93834.pdf Restricted Access | artigo original publicado | 343.03 kB | Adobe PDF | Request a copy from the Author(s) |
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