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dc.creatorSandra Rocha
dc.creatorMaria do Carmo Pereira
dc.creatorManuel A. N. Coelho
dc.creatorSílvia Castro Coelho
dc.creatorPetras Juzenas
dc.description.abstractGold nanoparticles are versatile vectors for biological applications including in cancer therapy and diagnosis. Combining gold nanoparticles/anticancer drugs with X-rays radiation may contribute to tumor eradication and treatment efficacy. The conjugation of a proteasome inhibitor (BTZ) with functionalized gold nanoparticles were tested. The drug activity and the anticancer effects in human prostate cancer cells (Du-145) were evaluated. It was observed that gold nanoparticles, with small diameters (24 nm), at concentrations of 0.1 nM are not toxic for Du-145 cells. Finally, nanoparticle parameters were discussed and new ideas are proposed to optimize the anticancer properties of conjugated gold nanoparticles leading to a better delivery of the drug, minimizing the side effects.
dc.relationinfo:eu-repo/grantAgreement/FCT - Fundação para a Ciência e a Tecnologia/Projectos de I&DT em Todos os Domínios Científicos/PTDC/QUI-BIQ/115449/2009/Distibuição de biomoleculas através de nanopartículas inorganica/organicas /BIONANO
dc.relation.ispartof3rd Portuguese Bioengineering Meeting, ENBENG 2013 - Book of Proceedings
dc.subjectBiotecnologia ambiental
dc.subjectEnvironmental biotechnology
dc.titleFunctionalized gold nanoparticles for drug delivery
dc.typeArtigo em Livro de Atas de Conferência Internacional
dc.contributor.uportoFaculdade de Engenharia
dc.subject.fosCiências da engenharia e tecnologias::Biotecnologia ambiental
dc.subject.fosEngineering and technology::Environmental biotechnology
Appears in Collections:FEUP - Artigo em Livro de Atas de Conferência Internacional

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