Please use this identifier to cite or link to this item: https://hdl.handle.net/10216/103248
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dc.creatorSandra Rocha
dc.creatorMaria do Carmo Pereira
dc.creatorManuel A. N. Coelho
dc.creatorSílvia Castro Coelho
dc.creatorPetras Juzenas
dc.date.accessioned2022-09-08T03:13:38Z-
dc.date.available2022-09-08T03:13:38Z-
dc.date.issued2013
dc.identifier.othersigarra:93834
dc.identifier.urihttps://hdl.handle.net/10216/103248-
dc.description.abstractGold nanoparticles are versatile vectors for biological applications including in cancer therapy and diagnosis. Combining gold nanoparticles/anticancer drugs with X-rays radiation may contribute to tumor eradication and treatment efficacy. The conjugation of a proteasome inhibitor (BTZ) with functionalized gold nanoparticles were tested. The drug activity and the anticancer effects in human prostate cancer cells (Du-145) were evaluated. It was observed that gold nanoparticles, with small diameters (24 nm), at concentrations of 0.1 nM are not toxic for Du-145 cells. Finally, nanoparticle parameters were discussed and new ideas are proposed to optimize the anticancer properties of conjugated gold nanoparticles leading to a better delivery of the drug, minimizing the side effects.
dc.language.isoeng
dc.relationinfo:eu-repo/grantAgreement/FCT - Fundação para a Ciência e a Tecnologia/Projectos de I&DT em Todos os Domínios Científicos/PTDC/QUI-BIQ/115449/2009/Distibuição de biomoleculas através de nanopartículas inorganica/organicas /BIONANO
dc.relation.ispartof3rd Portuguese Bioengineering Meeting, ENBENG 2013 - Book of Proceedings
dc.rightsrestrictedAccess
dc.subjectBiotecnologia ambiental
dc.subjectEnvironmental biotechnology
dc.titleFunctionalized gold nanoparticles for drug delivery
dc.typeArtigo em Livro de Atas de Conferência Internacional
dc.contributor.uportoFaculdade de Engenharia
dc.identifier.doi10.1109/enbeng.2013.6518389
dc.identifier.authenticusP-006-FH5
dc.subject.fosCiências da engenharia e tecnologias::Biotecnologia ambiental
dc.subject.fosEngineering and technology::Environmental biotechnology
Appears in Collections:FEUP - Artigo em Livro de Atas de Conferência Internacional

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