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Author(s): Joana A. Loureiro
Manuel A. N. Coelho
Sandra Rocha
Maria do Carmo Pereira
Title: Design of potential therapeutic peptides and carriers to inhibit amyloid beta peptide aggregation
Issue Date: 2012
Abstract: The conformational changes and aggregation of amyloid beta peptide (A beta) are associated to Alzheimer's disease (AD). The aim of this work is to study the structure and fibril assembly of A beta in the presence of charged and nonionic amphiphiles, and beta-sheet breaker peptides/conjugates. It is expected that these molecules will inhibit A beta aggregation. Liposome systems will be developed as carriers for these peptide conjugates to cross the brain blood barrier (BBB).
Subject: Biotecnologia ambiental
Environmental biotechnology
Scientific areas: Ciências da engenharia e tecnologias::Biotecnologia ambiental
Engineering and technology::Environmental biotechnology
Document Type: Artigo em Livro de Atas de Conferência Internacional
Rights: restrictedAccess
Appears in Collections:FEUP - Artigo em Livro de Atas de Conferência Internacional

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