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Author(s): João F C Carvalho
Sara Filipa Oliveira Durão
Pedro Sousa Gomes
Silva-marques, jm
Fonseca, hrm
Duarte, jar
Fernandes, mhr
Title: Bone Regeneration in Osteoporotic Conditions: Healing of Subcritical-Size Calvarial Defects in the Ovariectomized Rat
Issue Date: 2012
Abstract: Purpose: Osteoporosis is a pathologic condition characterized by low bone mass and changes in the microarchitecture of the bone tissue. Although compromised bone strength and increased susceptibility to fracture have been established, little is known regarding the process of bone regeneration in osteoporotic conditions. Accordingly, this study sought to evaluate the intramembranous bone regeneration process in an ovariectomized rat model following the establishment of calvarial subcritical-size defects (sCSDs). Materials and Methods: Calvarial sCSDs were established in rats that had been ovariectomized (Ovx) or sham-operated 2 months previously and left to heal, unfilled, for 6 months. Bone regeneration was assessed by radiographic, densitometric, histologic, and histometric analyses. Results: Radio logic and histologic analyses showed reduced new bone formation in calvarial sCSDs in Ovx animals in comparison to sham animals. Densitometric analysis of radiologic images and histometric analysis showed significant quantitative differences between groups that converged to substantiate reduced bone regeneration in Ovx animals. Conclusions: The intramembranous ossification process is impaired in the Ovx rat model. This may suggest an impairment of the bone regeneration process in clinical conditions of postmenopausal osteoporosis and highlight the requirement for selective bone regenerative strategies in affected patients. INT J ORAL MAXILLOFAC IMPLANTS 2012;27:1400-1408
Subject: Ciências da Saúde, Medicina clínica
Health sciences, Clinical medicine
Scientific areas: Ciências médicas e da saúde::Medicina clínica
Medical and Health sciences::Clinical medicine
Document Type: Artigo em Revista Científica Internacional
Rights: restrictedAccess
Appears in Collections:FADEUP - Artigo em Revista Científica Internacional
FMDUP - Artigo em Revista Científica Internacional

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