Please use this identifier to cite or link to this item:
Author(s): Leal, IS
Smedegard, B
Andersen, P
Appelberg, R
Title: Failure to induce enhanced protection against tuberculosis by increasing T-cell-dependent interferon-gamma generation
Issue Date: 2001
Abstract: We evaluated the use of recombinant human interleukin-6 (rhIL-6) and a monoclonal antibody specific for interferon-gamma (IFN-gamma) as co-adjuvants in a subunit vaccine against tuberculosis consisting of the culture filtrate proteins of Mycobacterium tuberculosis (ST-CF) emulsified in the adjuvant dimethyl-dioctadecylammonium bromide (DDA). Both the addition of rhIL-6 and the neutralization of IFN-gamma resulted in an increased T helper type 1 (Th1) response characterized by enhanced IFN-gamma production and cell proliferation. Nevertheless, this did not result in the enhancement of protection against either an intravenous or an aerosol M. tuberculosis challenge. Our data stress the need to identify further correlates of protection in addition to IFN-gamma production to screen vaccines against tuberculosis infection.
Subject: Infecções, Medicina básica
Infections, Basic medicine
Scientific areas: Ciências médicas e da saúde::Medicina básica
Medical and Health sciences::Basic medicine
Document Type: Artigo em Revista Científica Internacional
Rights: restrictedAccess
Appears in Collections:ICBAS - Artigo em Revista Científica Internacional

Files in This Item:
File Description SizeFormat 
  Restricted Access
162.22 kBUnknown    Request a copy from the Author(s)

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.