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Author(s): Angela França
Begoña Pérez-Cabezas
Alexandra Correia
Gerald B. pier
Nuno Cerca
Manuel Vilanova
Title: Staphylococcus epidermidis Biofilm-Released Cells Induce a Prompt and More Marked In vivo Inflammatory-Type Response than Planktonic or Biofilm Cells
Issue Date: 2016-09-27
Abstract: Staphylococcus epidermidis biofilm formation on indwelling medical devices is frequently associated with the development of chronic infections. Nevertheless, it has been suggested that cells released from these biofilms may induce severe acute infections with bacteraemia as one of its major associated clinical manifestations. However, how biofilm-released cells interact with the host remains unclear. Here, using a murine model of hematogenously disseminated infection, we characterized the interaction of cells released from S. epiderrnidis biofilms with the immune system. Gene expression analysis of mouse splenocytes suggested that biofilm-released cells might be particularly effective at activating inflammatory and antigen presenting cells and inducing cellular apoptosis. Furthermore, biofilm-released cells induced a higher production of pro-inflammatory cytokines, in contrast to mice infected with planktonic cells, even though these had a similar bacterial load in livers and spleens. Overall, these results not only provide insights into the understanding of the role of biofilm-released cells in S. epiderrnidis biofilm-related infections and pathogenesis, but may also help explain the relapsing character of these infections.
Subject: Microbiologia, Ciências biológicas
Microbiology, Biological sciences
Scientific areas: Ciências exactas e naturais::Ciências biológicas
Natural sciences::Biological sciences
Document Type: Artigo em Revista Científica Internacional
Rights: openAccess
Appears in Collections:ICBAS - Artigo em Revista Científica Internacional

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