Please use this identifier to cite or link to this item:
https://hdl.handle.net/10216/87501
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DC Field | Value | Language |
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dc.creator | Angela França | |
dc.creator | Begoña Pérez-Cabezas | |
dc.creator | Alexandra Correia | |
dc.creator | Gerald B. pier | |
dc.creator | Nuno Cerca | |
dc.creator | Manuel Vilanova | |
dc.date.accessioned | 2022-09-08T01:15:43Z | - |
dc.date.available | 2022-09-08T01:15:43Z | - |
dc.date.issued | 2016-09-27 | |
dc.identifier.issn | 1664-302X | |
dc.identifier.other | sigarra:159621 | |
dc.identifier.uri | https://hdl.handle.net/10216/87501 | - |
dc.description.abstract | Staphylococcus epidermidis biofilm formation on indwelling medical devices is frequently associated with the development of chronic infections. Nevertheless, it has been suggested that cells released from these biofilms may induce severe acute infections with bacteraemia as one of its major associated clinical manifestations. However, how biofilm-released cells interact with the host remains unclear. Here, using a murine model of hematogenously disseminated infection, we characterized the interaction of cells released from S. epiderrnidis biofilms with the immune system. Gene expression analysis of mouse splenocytes suggested that biofilm-released cells might be particularly effective at activating inflammatory and antigen presenting cells and inducing cellular apoptosis. Furthermore, biofilm-released cells induced a higher production of pro-inflammatory cytokines, in contrast to mice infected with planktonic cells, even though these had a similar bacterial load in livers and spleens. Overall, these results not only provide insights into the understanding of the role of biofilm-released cells in S. epiderrnidis biofilm-related infections and pathogenesis, but may also help explain the relapsing character of these infections. | |
dc.language.iso | eng | |
dc.rights | openAccess | |
dc.subject | Microbiologia, Ciências biológicas | |
dc.subject | Microbiology, Biological sciences | |
dc.title | Staphylococcus epidermidis Biofilm-Released Cells Induce a Prompt and More Marked In vivo Inflammatory-Type Response than Planktonic or Biofilm Cells | |
dc.type | Artigo em Revista Científica Internacional | |
dc.contributor.uporto | Instituto de Ciências Biomédicas Abel Salazar | |
dc.identifier.doi | 10.3389/fmicb.2016.01530 | |
dc.identifier.authenticus | P-00M-40G | |
dc.subject.fos | Ciências exactas e naturais::Ciências biológicas | |
dc.subject.fos | Natural sciences::Biological sciences | |
Appears in Collections: | ICBAS - Artigo em Revista Científica Internacional |
Files in This Item:
File | Description | Size | Format | |
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159621.pdf | 1.21 MB | Adobe PDF | View/Open |
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