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Author(s): Taras Kotyk
Nilanjan Dey
Amira S. Ashour
Dana Balas-Timar
Sayan Chakraborty
Ahmed S. Ashour
João Manuel R. S. Tavares
Title: Measurement of glomerulus diameter and Bowman's space width of renal albino rats
Issue Date: 2016
Abstract: Glomerulus diameter and Bowman's space width in renal microscopic images indicate various diseases. Therefore, the detection of the renal corpuscle and related objects is a key stepin histopathological evaluation of renal microscopic images. However, the task of automaticglomeruli detection is challenging due to their wide intensity variation, besides the inconsistency in terms of shape and size of the glomeruli in the renal corpuscle. Here, a novelsolution is proposed which includes the Particles Analyzer technique based on median filter for morphological image processing to detect the renal corpuscle objects. Afterwards,the glomerulus diameter and Bowman's space width are measured. The solution was testedwith a dataset of 21 rats' renal corpuscle images acquired using light microscope. The experimental results proved that the proposed solution can detect the renal corpuscle and itsobjects efficiently. As well as, the proposed solution has the ability to manage any inputimages assuring its robustness to the deformations of the glomeruli even with the glomerular hypertrophy cases. Also, the results reported significant difference between the controland affected (due to ingested additional daily dose (14.6mg) of fructose) groups in terms ofglomerulus diameter (97.40 ± 19.02m and 177.03 ± 54.48m, respectively).
Subject: Ciências Tecnológicas, Ciências médicas e da saúde
Technological sciences, Medical and Health sciences
Scientific areas: Ciências médicas e da saúde
Medical and Health sciences
Document Type: Artigo em Revista Científica Internacional
Rights: openAccess
Appears in Collections:FEUP - Artigo em Revista Científica Internacional

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