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Author(s): Madalena Silva
Luís M. M. Vieira
Ana Paula Almeida
Artur M. S. Silva
Ana M. L. Seca
M. Carmo Barreto
Ana I. Neto
Madalena Pedro
Eugénia Pinto
Anake Kijjoa
Title: Chemical Study and Biological Activity Evaluation of Two Azorean Macroalgae:Ulva rigida and Gelidium microdon
Issue Date: 2013
Abstract: The green macroalga Ulva rigida C. Agardh (Chlorophyta) and the red macroalga Gelidium microdon Kützing(Rhodophyta), collected from the Azorean archipelago, were investigated for their secondary metabolites and their invitro growth inhibitory effect on three human tumor cell lines: MCF-7 (breast adenocarcinoma), NCI-H460 (non-small celllung cancer) and A375-C5 (melanoma), as well as for their antifungal and antibacterial activities. The methanol extractof U. rigida furnished isofucosterol (1), 7(E)-3β-hydroxy-5α,6α-epoxymegastigmane (2) and (+)-dehydrovomifoliol (3)while the methanol extract of G. microdon yielded cholesterol (4) and lumichrome (5). The crude extracts of bothmacroalgae were found to be moderately active against the three cell lines whereas compound 1 showed a weak effectand compound 2 was inactive. The crude extracts of the two macroalgae were found to be moderately active againstsome fungi and bacteria while compounds 1 and 2 were inactive against all microorganisms tested.
Subject: Ciências biológicas, Ciências biológicas
Biological sciences, Biological sciences
Scientific areas: Ciências exactas e naturais::Ciências biológicas
Natural sciences::Biological sciences
Document Type: Artigo em Revista Científica Internacional
Rights: openAccess
Appears in Collections:FFUP - Artigo em Revista Científica Internacional
ICBAS - Artigo em Revista Científica Internacional

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