Please use this identifier to cite or link to this item:
https://hdl.handle.net/10216/81233
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Rosa Pereira | |
dc.creator | Tommy Julianto | |
dc.creator | Peh Kim Ang | |
dc.creator | Sharon Sheue Nee Ling | |
dc.creator | Carlos Mauricio Barbosa | |
dc.creator | Kah Hay Yuen | |
dc.creator | Abu Bakar Abdul Majeed | |
dc.date.accessioned | 2022-09-11T23:32:37Z | - |
dc.date.available | 2022-09-11T23:32:37Z | - |
dc.date.issued | 2010 | |
dc.identifier.issn | 0009-5893 | |
dc.identifier.other | sigarra:103248 | |
dc.identifier.uri | https://hdl.handle.net/10216/81233 | - |
dc.description.abstract | A sensitive and rapid routine LC method was validated for measuring cefotaxime incorporated in three different pH-sensitive nanoparticles. The drug was chromatographed on a C18 reversed-phase column; the mobile phase used was 0.05 M aqueous ammonium acetate, acetonitrile and tetrahydrofuran (87:11:2, v/v) adjusted to pH 5.5 with acetic acid. The flow rate was 1 mL min(-1) and cefotaxime was quantified at 254 nm, with a sensitivity range of 0.005 AUFS. The validated method was specific, linear (R (2) a parts per thousand yen 0.999), precise and accurate in a concentration range of 0.2-50.0 mu g mL(-1). The method was rapid, selective and suitable for evaluation of cefotaxime in pH-sensitive Eudragit nanoparticles. | |
dc.language.iso | eng | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | |
dc.subject | Química | |
dc.subject | Chemical sciences | |
dc.title | A Validated LC Method for the Quantitation of Cefotaxime in pH-Sensitive Nanoparticles | |
dc.type | Artigo em Revista Científica Internacional | |
dc.contributor.uporto | Faculdade de Farmácia | |
dc.identifier.doi | 10.1365/s10337-010-1481-5 | |
dc.identifier.authenticus | P-003-8G6 | |
dc.subject.fos | Ciências exactas e naturais::Química | |
dc.subject.fos | Natural sciences::Chemical sciences | |
Appears in Collections: | FFUP - Artigo em Revista Científica Internacional |
Files in This Item:
File | Description | Size | Format | |
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103248.pdf | 444.09 kB | Adobe PDF | View/Open |
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