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Author(s): Dina M. Silva
Daniella L. Morgado
Thierry Delair
Laurent David
Sophie Rouif
José Luis López-Lacomba
Ana Colette Maurício
José Domingos Santos
Francisco M. Gama
Title: Potential of injectable dextrin-based hydrogel for biomedical applications
Issue Date: 2014
Abstract: Bone tissue engineering is a very challenging and promising field, which handles withthe limitations of bone regenerative capacity and the failure of current orthopedicimplants [1].This work describes the preparation and characterization of an injectable dextrinbasedhydrogel (oDex) through dextrin oxidation followed by cross-linking with adihydrazide [2]. In vitro and in vivo experiments allowed to conclude that this systemcan carry and stabilize cells, nanogels, Bonelike® granules [3] and other biomolecules.This is a promising biomaterial due to its biocompatibility, and potential to promote anadequate environment for bone regeneration, which was increased by the combinedbioactive molecules. Its injectability allows a minimal invasive surgical procedure withdecreased patient morbidity, lower infection risk and reduced scar formation.Furthermore, an adequate sterilization protocol for this kind of material wasestablished.The tight collaboration between University of Minho and Bioskin S.A. company,envisioning technology transfer and product valorization, has resulted in a publishedinternational patent of the product (WO2011070529A2) [4]. Currently, the submissionof a request for the authorization for the clinical trials is being planned.
Subject: Engenharia biomédica, Biotecnologia médica
Biomedical enginnering, Medical biotechnology
Scientific areas: Ciências médicas e da saúde::Biotecnologia médica
Medical and Health sciences::Medical biotechnology
Source: Polymer and Fiber Biotechnology
Related Information: info:eu-repo/grantAgreement/FCT - Fundação para a Ciência e Tecnologia/Projectos de Cooperação Internacional/ENMED/0002/2010/Hidrogeis híbridos nanoestruturados: hidrogeis multifuncionais injetáveis para regeneração óssea/REBONE
Document Type: Artigo em Livro de Atas de Conferência Internacional
Rights: openAccess
Appears in Collections:FEUP - Artigo em Livro de Atas de Conferência Internacional
ICBAS - Artigo em Livro de Atas de Conferência Internacional

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