Please use this identifier to cite or link to this item: https://hdl.handle.net/10216/78356
Author(s): Paula Vaz
Sampaio-Fernandes J.
A.C. Braga
Maria João Ponces
António Felino
Title: IL-1 polymorphisms may predict unsuccessful dental implants?
Issue Date: 2012
Abstract: AimThe aim of this study was to analyse the possible association between no success of dental implants and two polymorphisms, IL1A (-889) and IL1B (+3953), in a Caucasian Portuguese population, and a possible relationship with other potential risk variables associated with a peri-implant disease.Material and Methods155 unrelated Caucasian individuals, were divided into 2 groups: 100 with successful dental implant rehabilitations and 55 with unsuccessful ones. To identify the polymorphisms, in positions -889 of IL1A gene and +3953 of IL1B gene, was performed an oral mucosa scraping of the patients and the DNA obtained from epithelial cells. The data were analysed in the SPSS Statistics 17.0® and the statistic analysis included the independence test of the chi-square, the exact test of Fisher and techniques of analysis of binary logistic regression.ResultsThe estimated prevalence of polymorphisms of IL1A and IL1B gene, determined by the TGP (CGC Genetics, Portugal) results, in the Caucasian Portuguese population was of 33.5%.Success of rehabilitation with dental implants was more associated to a negative TGP result, whereas failure was found to be related to a positive result.Tobacco and alcohol consumption showed no statistically significant association with success or no success of the dental implants.ConclusionThe success of the dental implants was more associated with the presence of the allele 2 of the IL1A gene and the allele 2 of the IL1B gene.Tobacco and alcohol consumption showed no association with success or no success of the rehabilitation with dental implants.
Subject: Ciências da Saúde, Ciências médicas e da saúde
Health sciences, Medical and Health sciences
Scientific areas: Ciências médicas e da saúde
Medical and Health sciences
URI: https://repositorio-aberto.up.pt/handle/10216/78356
Source: Europerio 7
Document Type: Resumo de Comunicação em Conferência Internacional
Rights: openAccess
License: https://creativecommons.org/licenses/by-nc/4.0/
Appears in Collections:FMDUP - Resumo de Comunicação em Conferência Internacional

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