Please use this identifier to cite or link to this item: https://hdl.handle.net/10216/69110
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dc.creatorFlorido, M
dc.creatorBorges, M
dc.creatorYagita, H
dc.creatorAppelberg, R
dc.date.accessioned2019-02-01T17:17:25Z-
dc.date.available2019-02-01T17:17:25Z-
dc.date.issued2004
dc.identifier.issn0741-5400
dc.identifier.othersigarra:88196
dc.identifier.urihttps://repositorio-aberto.up.pt/handle/10216/69110-
dc.description.abstractA panel of monoclonal antibodies specific for CD27 ligand (CD70), CD30 ligand (CD153), CD134 ligand (OX40L), and CD137 ligand (4-1BBL) were screened in vivo for their ability to affect the control of Mycobacterium avium infection in C57B1/6 mice. Only the blocking of CD153 led to increased mycobacterial burdens. We then used CD30-deficient mice and found an increase in the proliferation of two strains of M. avium in these mice as compared with control animals. The increased mycobacterial growth was associated with decreased T cell expansion and reduced interferon-gamma (IFN-gamma) responses as a result of reduced polarization of the antigen-specific, IFN-gamma-producing T cells. At late times but not early in infection, the lymphoid cuff surrounding granulomas was depleted in the CD30-deficient animals. This report expands our knowledge about tumor necrosis factor superfamily members involved in the immune responses to mycobacterial infection by identifying CD30-CD153 interactions as required for optimal immune control of M. avium infection.
dc.language.isoeng
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.subjectInfecções, Medicina clínica
dc.subjectInfections, Clinical medicine
dc.titleContribution of CD30/CD153 but not of CD27/CD70, CD134/OX40L, or CD137/4-1BBL to the optimal induction of protective immunity to Mycobacterium avium
dc.typeArtigo em Revista Científica Internacional
dc.contributor.uportoFaculdade de Farmácia
dc.contributor.uportoInstituto de Ciências Biomédicas Abel Salazar
dc.identifier.doi10.1189/jlb.1103572
dc.identifier.authenticusP-000-7Y1
dc.subject.fosCiências médicas e da saúde::Medicina clínica
dc.subject.fosMedical and Health sciences::Clinical medicine
Appears in Collections:FFUP - Artigo em Revista Científica Internacional
ICBAS - Artigo em Revista Científica Internacional

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