Please use this identifier to cite or link to this item: https://hdl.handle.net/10216/68006
Author(s): Maria João Ponces
Paula Vaz
Fred Pinheiro
Inês Côrte-Real
Purificação Tavares
Title: Root Resorption in Orthodontics - Genetic Susceptibility?
Issue Date: 2011
Abstract: OBJECTIVES: External root resorption (ERR) is a condition that can be observed in association with orthodontic treatment. The etiology of root resorption is complex, related with several factors. Some inflammatory mediators, controlled by specific genes, have been associated with bone resorption and in the recruitment of osteoclasts during orthodontic movement (Lee et al., 2007; Abass et al., 2008; Bastos et al., 2009). Particularly the association between polymorphisms in the IL-1B gene and ERR during orthodontic treatment has been referenced in literature. The present paper as the principal objective to present a case of an orthodontic patient, Caucasian, gender male, 15 years old, with positive family history of generalized ERR associated to orthodontic treatment (one sister), and there was therefore need to clarify the role of genetic susceptibility in its pathogenesis. MATERIALS AND METHODS: It was performed a literature review on PUBMED with the key words dental orthodontics resorption genetics, 12 articles were obtained and were included 8 of these. There were also associated with the theme 7 more articles, from the list of related articles. The search was limited to the last 10 years and the English, French and Spanish. RESULTS: As there was positive family history of the ERR was decided to perform a genetic test for determination of single polymorphisms for IL1B gene (TGP, CGC Clinical Genetics Center, Portugal), which revealed the presence of an allele of the IL1B gene - positive result for ERR. The absence of external etiological factors associated with orthodontic treatment was suggestive of possible individual genetic susceptibility. CONCLUSIONS: The identification of individuals with increased susceptibility to ERR should be considered during the orthodontic treatment plan, to allow adjustments necessary in terms of magnitude of the force to be applied, both in terms of duration of treatment.
Subject: Ciências da Saúde, Outras ciências médicas
Health sciences, Other medical sciences
Scientific areas: Ciências médicas e da saúde::Outras ciências médicas
Medical and Health sciences::Other medical sciences
URI: https://repositorio-aberto.up.pt/handle/10216/68006
Source: European Journal of Orthodontics
Document Type: Resumo de Comunicação em Conferência Internacional
Rights: openAccess
License: https://creativecommons.org/licenses/by-nc/4.0/
Appears in Collections:FMDUP - Resumo de Comunicação em Conferência Internacional

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