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Author(s): Rui Camacho
Alexessander Alves
Cândida G. Silva
Rui M. M. Brito
Title: On mining protein unfolding simulation data with inductive logic programming
Issue Date: 2008
Abstract: The detailed study of folding and unfolding events in proteins is becoming central to develop rational therapeutic strategies against maladies such asAlzheimer and Parkinson disease. A promising approach to study the unfolding processes of proteins is through computer simulations. However, these computer simulations generate huge amounts of data that require computational methods for their analysis.In this paper we report on the use of Inductive Logic Programming (ILP) techniques to analyse the trajectories of protein unfolding simulations. The paper describes ongoing work on one of several problems of interest in the protein unfolding setting. The problem we address here is that of explaining what makes secondary structure elements to break down during the unfolding process. We tackle such problem collecting examples of contexts where secondary structures break and (automatically) constructing rules that may be used to suggest the explanations.
Subject: Engenharia do conhecimento, Engenharia electrotécnica, electrónica e informática
Knowledge engineering, Electrical engineering, Electronic engineering, Information engineering
Scientific areas: Ciências da engenharia e tecnologias::Engenharia electrotécnica, electrónica e informática
Engineering and technology::Electrical engineering, Electronic engineering, Information engineering
Source: 2nd International Workshop on Practical Applications of Computational Biology & Bioinformatics (IWPACBB 2008)
Document Type: Artigo em Livro de Atas de Conferência Internacional
Rights: openAccess
Appears in Collections:FEUP - Artigo em Livro de Atas de Conferência Internacional

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