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Author(s): Bessa, MJ
Brandão, F
Rosário, F
Moreira, L
Reis, AT
Valdiglesias, V
Laffon, B
Fraga, S
Teixeira, JP
Title: Assessing the in vitro toxicity of airborne (nano)particles to the human respiratory system: from basic to advanced models
Publisher: Taylor and Francis Group
Issue Date: 2023
Abstract: Several studies have been conducted to address the potential adverse health risks attributed to exposure to nanoscale materials. While in vivo studies are fundamental for identifying the relationship between dose and occurrence of adverse effects, in vitro model systems provide important information regarding the mechanism(s) of action at the molecular level. With a special focus on exposure to inhaled (nano)particulate material toxicity assessment, this review provides an overview of the available human respiratory models and exposure systems for in vitro testing, advantages, limitations, and existing investigations using models of different complexity. A brief overview of the human respiratory system, pathway and fate of inhaled (nano)particles is also presented.
Subject: Nanoparticles
respiratory models
in vitro
submerged cultures
air-liquid interface
toxicity testing
Source: J Toxicol Environ Health B Crit Rev. 2023 Feb 17;26(2):67-96. doi: 10.1080/10937404.2023.2166638. Epub 2023 Jan 24.
Related Information: info:eu-repo/grantAgreement/FCT/POR_NORTE/SFRH/BPD/122112/2016/PT
info:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC/MED-TOX/31162/2017/PT
info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB/04750/2020/PT
Document Type: Artigo em Revista Científica Internacional
Rights: openAccess
Appears in Collections:ISPUP - Artigo em Revista Científica Internacional

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