Please use this identifier to cite or link to this item: https://hdl.handle.net/10216/154246
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dc.creatorBessa, MJ
dc.creatorBrandão, F
dc.creatorRosário, F
dc.creatorMoreira, L
dc.creatorReis, AT
dc.creatorValdiglesias, V
dc.creatorLaffon, B
dc.creatorFraga, S
dc.creatorTeixeira, JP
dc.date.accessioned2023-11-14T11:30:05Z-
dc.date.available2023-11-14T11:30:05Z-
dc.date.issued2023
dc.identifier.issn1093-7404
dc.identifier.issn1521-6950
dc.identifier.urihttps://hdl.handle.net/10216/154246-
dc.description.abstractSeveral studies have been conducted to address the potential adverse health risks attributed to exposure to nanoscale materials. While in vivo studies are fundamental for identifying the relationship between dose and occurrence of adverse effects, in vitro model systems provide important information regarding the mechanism(s) of action at the molecular level. With a special focus on exposure to inhaled (nano)particulate material toxicity assessment, this review provides an overview of the available human respiratory models and exposure systems for in vitro testing, advantages, limitations, and existing investigations using models of different complexity. A brief overview of the human respiratory system, pathway and fate of inhaled (nano)particles is also presented.
dc.description.sponsorshipThe work was supported by the Fundacao para a Ciencia e a Tecnologia [POCI-01-0145-FEDER-029651, SFRH/BPD/122112/2016,PTDC/MED-TOX/31162/2017, DL-57/INSA-06/2018,SFRH/BD/101060/2014,SFRH/BD/120646/2016,SIINN/0004/2014,UIDB/04750/2020, LA/P/0064/2020]; Spanish Ministry of Education, Culture and Sport [BEAGAL18/00142]; Spanish Ministry of Science and Innovation [PID2020-114908GA-I00].
dc.language.isoeng
dc.publisherTaylor and Francis Group
dc.relationinfo:eu-repo/grantAgreement/FCT/POR_NORTE/SFRH/BPD/122112/2016/PT
dc.relationinfo:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC/MED-TOX/31162/2017/PT
dc.relationinfo:eu-repo/grantAgreement/FCT/OE/SFRH/BD/101060/2014/PT
dc.relationinfo:eu-repo/grantAgreement/FCT/POR_NORTE/SFRH/BD/120646/2016/PT
dc.relationinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/SIINN/0004/2014/PT
dc.relationinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB/04750/2020/PT
dc.relation.ispartofJ Toxicol Environ Health B Crit Rev. 2023 Feb 17;26(2):67-96. doi: 10.1080/10937404.2023.2166638. Epub 2023 Jan 24.
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectNanoparticles
dc.subjectrespiratory models
dc.subjectin vitro
dc.subjectsubmerged cultures
dc.subjectair-liquid interface
dc.subjecttoxicity testing
dc.titleAssessing the in vitro toxicity of airborne (nano)particles to the human respiratory system: from basic to advanced models
dc.typeArtigo em Revista Científica Internacional
dc.contributor.uportoInstituto de Saúde Pública da Universidade do Porto
dc.identifier.doi10.1080/10937404.2023.2166638
dc.relation.publisherversionhttps://www.tandfonline.com/doi/full/10.1080/10937404.2023.2166638
Appears in Collections:ISPUP - Artigo em Revista Científica Internacional

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