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Author(s): Maia, J
Otake, AH
Poças, J
Carvalho, AS
Beck, HC
Magalhães, A
Matthiesen, R
Strano Moraes, MC
Costa-Silva, B
Title: Transcriptome Reprogramming of CD11b(+) Bone Marrow Cells by Pancreatic Cancer Extracellular Vesicles
Publisher: Frontiers Media
Issue Date: 2020
Abstract: Pancreatic cancers (PC) are highly metastatic with poor prognosis, mainly due to delayed detection. We previously showed that PC-derived extracellular vesicles (EVs) act on macrophages residing in the liver, eliciting extracellular matrix remodeling in this organ and marked hepatic accumulation of CD11b+ bone marrow (BM) cells, which support PC liver metastasis. We here show that PC-EVs also bind to CD11b+ BM cells and induce the expansion of this cell population. Transcriptomic characterization of these cells shows that PC-EVs upregulate IgG and IgA genes, which have been linked to the presence of monocytes/macrophages in tumor microenvironments. We also report here the transcriptional downregulation of genes linked to monocyte/macrophage activation, trafficking, and expression of inflammatory molecules. Together, these results show for the first time the existence of a PC–BM communication axis mediated by EVs with a potential role in PC tumor microenvironments.
Subject: Cancer
Extracellular vesicles
Pancreatic cancer
Tumor microenvironment
Source: Frontiers in Cell and Developmental Biology, vol.8:592518
Related Information: info:eu-repo/grantAgreement/FCT/OE/PD%2FBD%2F105866%2F2014/PT
info:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FMED-ONC%2F28489%2F2017/PT
Document Type: Artigo em Revista Científica Internacional
Rights: openAccess
Appears in Collections:I3S - Artigo em Revista Científica Internacional

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