Utilize este identificador para referenciar este registo:
https://hdl.handle.net/10216/145270
Autor(es): | Maia, J Otake, AH Poças, J Carvalho, AS Beck, HC Magalhães, A Matthiesen, R Strano Moraes, MC Costa-Silva, B |
Título: | Transcriptome Reprogramming of CD11b(+) Bone Marrow Cells by Pancreatic Cancer Extracellular Vesicles |
Editor: | Frontiers Media |
Data de publicação: | 2020 |
Resumo: | Pancreatic cancers (PC) are highly metastatic with poor prognosis, mainly due to delayed detection. We previously showed that PC-derived extracellular vesicles (EVs) act on macrophages residing in the liver, eliciting extracellular matrix remodeling in this organ and marked hepatic accumulation of CD11b+ bone marrow (BM) cells, which support PC liver metastasis. We here show that PC-EVs also bind to CD11b+ BM cells and induce the expansion of this cell population. Transcriptomic characterization of these cells shows that PC-EVs upregulate IgG and IgA genes, which have been linked to the presence of monocytes/macrophages in tumor microenvironments. We also report here the transcriptional downregulation of genes linked to monocyte/macrophage activation, trafficking, and expression of inflammatory molecules. Together, these results show for the first time the existence of a PC–BM communication axis mediated by EVs with a potential role in PC tumor microenvironments. |
Assunto: | Cancer Exosomes Extracellular vesicles Macrophages Metastasis Monocytes Pancreatic cancer Tumor microenvironment |
URI: | https://hdl.handle.net/10216/145270 |
Fonte: | Frontiers in Cell and Developmental Biology, vol.8:592518 |
Informação Relacionada: | info:eu-repo/grantAgreement/FCT/OE/PD%2FBD%2F105866%2F2014/PT info:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FMED-ONC%2F28489%2F2017/PT info:eu-repo/grantAgreement/FCT/POR_NORTE/SFRH%2FBD%2F137319%2F2018/PT |
Tipo de Documento: | Artigo em Revista Científica Internacional |
Condições de Acesso: | openAccess |
Licença: | https://creativecommons.org/licenses/by/4.0/ |
Aparece nas coleções: | I3S - Artigo em Revista Científica Internacional |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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10.3389-fcell.2020.592518.pdf | 1.29 MB | Adobe PDF | Ver/Abrir |
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