Efeitos do Exercício físico regular na prevenção da cardiotoxicidade associado ao uso crónico da Doxorrubicina

Abstract

Many survivors of chemotherapy experience, in the medium to long term, serious side effects that compromise their health and quality of life, as with cardiotoxicity resulting from the administration of doxorubicin. The influence of physical exercise programs on the use of drugs is still poorly understood, despite this, some research has investigated the effects of regular physical exercises on the administration of doxorubicin, however, most studies have evaluated the effects of exercise after the acute administration of a single dose of the drug. To assess the current evidence base, the present study conducted a systematic review of the effects of regular exercise on cardiotoxicity induced by chronic administration of doxorubicin, as well as with patients who use it in the treatment of cancer. A total of 9 studies were identified on dose-response and mechanisms of action, it is important to report that the current evidence base has considerable methodological heterogeneity, preventing significant comparisons and conclusions regarding the influence of the intensity, frequency and duration of the physical exercise program. However, it is concluded that even low intensity exercise programs can favor the redox balance and attenuate the cardiotoxic effects provided by the use of doxorubicin through the evaluation of biomarkers that identify cardiotoxicity.