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Author(s): Gutiérrez-Del-Río, I.
de Fraissinette, N.B.
Castelo-Branco, R.
Oliveira, F.
Morais, J.
Redondo-Blanco, S.
Villar, C.J.
José Iglesias, M.
Soengas, R.
Cepas, V.
Cubillos, Y.L.
Sampietro, G.
Rodolfi, L.
Lombo, F.
Soto Gonzaléz, S.M.
Ortiz, F.L.
Vasconcelos, V.
Reis, M.A.
Title: Chlorosphaerolactylates A−D: Natural lactylates of chlorinated fatty acids isolated from the cyanobacterium sphaerospermopsis sp. Lege 00249
Publisher: American Chemical Society
Issue Date: 2020
Abstract: Four natural lactylates of chlorinated fatty acids, chlorosphaerolactylates A−D (1−4), were isolated from the methanolic extract of the cyanobacterium Sphaerospermopsis sp. LEGE 00249 through a combination of bioassay-guided and MS-guided approaches. Compounds 1−4 are esters of (mono-, di-, or tri)chlorinated lauric acid and lactic acid, whose structures were assigned on the basis of spectrometric and spectroscopic methods inclusive of 1D and 2D NMR experiments. High-resolution mass-spectrometry data sets also demonstrated the existence of other minor components that were identified as chlorosphaero(bis)-lactylate analogues. The chlorosphaerolactylates were tested for potential antibacterial, antifungal, and antibiofilm properties using bacterial and fungal clinical isolates. Compounds 1−4 showed a weak inhibitory effect on the growth of Staphylococcus aureus S54F9 and Candida parapsilosis SMI416, as well as on the biofilm formation of coagulase-negative Staphylococcus hominis FI31.
Source: Journal of Natural Products 2020, 83, 6, 1885–1890
Document Type: Artigo em Revista Científica Internacional
Rights: restrictedAccess
Appears in Collections:CIIMAR - Artigo em Revista Científica Internacional

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