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https://hdl.handle.net/10216/130484
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DC Field | Value | Language |
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dc.creator | Gutiérrez-Del-Río, I. | |
dc.creator | de Fraissinette, N.B. | |
dc.creator | Castelo-Branco, R. | |
dc.creator | Oliveira, F. | |
dc.creator | Morais, J. | |
dc.creator | Redondo-Blanco, S. | |
dc.creator | Villar, C.J. | |
dc.creator | José Iglesias, M. | |
dc.creator | Soengas, R. | |
dc.creator | Cepas, V. | |
dc.creator | Cubillos, Y.L. | |
dc.creator | Sampietro, G. | |
dc.creator | Rodolfi, L. | |
dc.creator | Lombo, F. | |
dc.creator | Soto Gonzaléz, S.M. | |
dc.creator | Ortiz, F.L. | |
dc.creator | Vasconcelos, V. | |
dc.creator | Reis, M.A. | |
dc.date.accessioned | 2020-12-04T15:18:41Z | - |
dc.date.available | 2020-12-04T15:18:41Z | - |
dc.date.issued | 2020 | |
dc.identifier.issn | ISSN 1520-6025 | |
dc.identifier.uri | https://hdl.handle.net/10216/130484 | - |
dc.description.abstract | Four natural lactylates of chlorinated fatty acids, chlorosphaerolactylates A−D (1−4), were isolated from the methanolic extract of the cyanobacterium Sphaerospermopsis sp. LEGE 00249 through a combination of bioassay-guided and MS-guided approaches. Compounds 1−4 are esters of (mono-, di-, or tri)chlorinated lauric acid and lactic acid, whose structures were assigned on the basis of spectrometric and spectroscopic methods inclusive of 1D and 2D NMR experiments. High-resolution mass-spectrometry data sets also demonstrated the existence of other minor components that were identified as chlorosphaero(bis)-lactylate analogues. The chlorosphaerolactylates were tested for potential antibacterial, antifungal, and antibiofilm properties using bacterial and fungal clinical isolates. Compounds 1−4 showed a weak inhibitory effect on the growth of Staphylococcus aureus S54F9 and Candida parapsilosis SMI416, as well as on the biofilm formation of coagulase-negative Staphylococcus hominis FI31. | |
dc.description.sponsorship | This work was funded by the European Commission under the H2020 program, NoMorFilm Project (Grant Agreement 634588). CIIMAR was additionally supported by the FCT strategic funds UIDB/04423/2020 and UIDP/04423/2020. R.C.B. acknowledges financial support from Fundação para a Ciência e Tecnologia (FCT) fellowship SFRH/BD/136367/2018. University of Oviedo also thanks Programa de Ayudas a Grupos de Investigación del Principado de Asturias (IDI/2018/000120) and Programa Severo Ochoa de Ayudas Predoctorales para la Investigación y Docencia from Principado de Asturias (Grant BP16023 to I.G.R.). HRESIMS experiments were conducted at the mass spectrometry unit of the University of Oviedo (Servicios Cientifico-Tećnicos). ISGlobal is a CERCA center from the Generalitat of Catalunya and a Severo Ochoa Center (Spanish Ministry of Science,Innovations and Universities supported by Planes Nacionales de I+D+i 2008-2011/2013-2016 and Instituto de Salud Carlos. II, Subdirección General de Redes y Centros de Investigación Cooperativa, Ministerio de Economia y Competitividad, Spanish Network for Research in Infectious Diseases (REIPI RD12/0015/0013 and REIPIRD16/0016/0010) cofinanced by the European Development Regional Fund “A Way to Achieve Europe” and operative program Intelligent Growth 2014−2020. The authors acknowledge the support and the use of resources of EMBRC-ERIC, specifically of the Portuguese infrastructure node of the European Marine Biological Resource Centre (EMBRC-PT) CIIMAR−PINFRA/22121/ 2016−ALG-01-0145-FEDER-022121, financed by the European Regional Development Fund (ERDF) through COM-PETE2020−Operational Programme for Competitiveness and Internationalisation (POCI) and national funds through FCT/ MCTES. | |
dc.language.iso | eng | |
dc.publisher | American Chemical Society | |
dc.relation.ispartof | Journal of Natural Products 2020, 83, 6, 1885–1890 | |
dc.rights | restrictedAccess | |
dc.title | Chlorosphaerolactylates A−D: Natural lactylates of chlorinated fatty acids isolated from the cyanobacterium sphaerospermopsis sp. Lege 00249 | |
dc.type | Artigo em Revista Científica Internacional | |
dc.contributor.uporto | Centro Interdisciplinar de Investigação Marinha e Ambiental | |
dc.identifier.doi | https://doi.org/10.1021/acs.jnatprod.0c00072 | |
dc.relation.publisherversion | https://pubs.acs.org/doi/abs/10.1021/acs.jnatprod.0c00072 | |
Appears in Collections: | CIIMAR - Artigo em Revista Científica Internacional |
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File | Description | Size | Format | |
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Gutierrez_Del_Rio_I_2020.pdf Restricted Access | 1.7 MB | Adobe PDF | Request a copy |
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