Please use this identifier to cite or link to this item:
https://hdl.handle.net/10216/129833
Author(s): | Guillen, P Gegunde, S Jaramillo, K Alfonso, A Calabro, K Alonso, E Rodriguez, J Botana, L Thomas, O |
Title: | Zoanthamine Alkaloids from the Zoantharian Zoanthus cf. pulchellus and Their Effects in Neuroinflammation |
Publisher: | MDPI |
Issue Date: | 2018 |
Abstract: | Two new zoanthamine alkaloids, namely 3-acetoxynorzoanthamine (1) and 3-acetoxyzoanthamine (2), have been isolated from the zoantharian Zoanthus cf. pulchellus collected off the coast of the Santa Elena Peninsula, Ecuador, together with three known derivatives: zoanthamine, norzoanthamine, and 3-hydroxynorzoanthamine. The chemical structures of 1 and 2 were determined by interpretation of their 1D and 2D NMR data and comparison with literature data. This is the first report of zoanthamine-type alkaloids from Zoanthus cf. pulchellus collected in the Tropical Eastern Pacific. The neuroinflammatory activity of all the isolated compounds was evaluated in microglia BV-2 cells and high inhibitory effects were observed in reactive oxygen species (ROS) and nitric oxide (NO) generation. |
Subject: | zoantharia Tropical Eastern Pacific Zoanthus pulchellus zoanthamine inflammation |
URI: | https://hdl.handle.net/10216/129833 |
Series: | Mar. Drugs 2018, 16(7), 242 |
Document Type: | Artigo em Revista Científica Internacional |
Rights: | openAccess |
Appears in Collections: | CIIMAR - Artigo em Revista Científica Internacional |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Guillen_P_2018.pdf | 1.19 MB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.