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  3. CIIMAR - Artigo em Revista Científica Internacional
Please use this identifier to cite or link to this item: https://hdl.handle.net/10216/129833
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dc.creatorGuillen, P-
dc.creatorGegunde, S-
dc.creatorJaramillo, K-
dc.creatorAlfonso, A-
dc.creatorCalabro, K-
dc.creatorAlonso, E-
dc.creatorRodriguez, J-
dc.creatorBotana, L-
dc.creatorThomas, O-
dc.date.accessioned2020-11-06T17:13:23Z-
dc.date.available2020-11-06T17:13:23Z-
dc.date.issued2018-
dc.identifier.urihttps://hdl.handle.net/10216/129833-
dc.description.abstractTwo new zoanthamine alkaloids, namely 3-acetoxynorzoanthamine (1) and 3-acetoxyzoanthamine (2), have been isolated from the zoantharian Zoanthus cf. pulchellus collected off the coast of the Santa Elena Peninsula, Ecuador, together with three known derivatives: zoanthamine, norzoanthamine, and 3-hydroxynorzoanthamine. The chemical structures of 1 and 2 were determined by interpretation of their 1D and 2D NMR data and comparison with literature data. This is the first report of zoanthamine-type alkaloids from Zoanthus cf. pulchellus collected in the Tropical Eastern Pacific. The neuroinflammatory activity of all the isolated compounds was evaluated in microglia BV-2 cells and high inhibitory effects were observed in reactive oxygen species (ROS) and nitric oxide (NO) generation.pt_PT
dc.description.sponsorshipThe project is originally funded by the Secretaria de Educación Superior, Ciencia, Tecnología e Innovación (SENESCYT) in the framework of the PIC-14-CENAIM-001 Project Caracterización de la Biodiversidad Microbiológica y de Invertebrados de la Reserva Marina “El Pelado” a Escala Taxonómica, Metabolómica y Metagenómica para su Uso en Salud Humana y Animal. Part of this project (Grant-Aid Agreement No. PBA/MB/16/01) is carried out with the support of the Marine Institute and is funded under the Marine Research Programme by the Irish Government. P.O.G. and K.B.J. acknowledge NUI Galway for supporting part of their Ph.D. scholarship. The research leading to the results of the biological assays has received funding from the following FEDER cofunded-grants: Consellería de Cultura, Educación e Ordenación Universitaria, Xunta de Galicia, 2017 GRC GI-1682 (ED431C 2017/01); CDTI and Technological Funds, supported by Ministerio de Economía, Industria y Competitividad, AGL2014-58210-R, AGL2016-78728-R (AEI/FEDER, UE), ISCIII/PI16/01830 and RTC-2016-5507-2, ITC-20161072; European Union POCTEP 0161-Nanoeaters-1-E-1, Interreg AlertoxNet EAPA-317-2016, and H2020 778069-EMERTOX.pt_PT
dc.language.isoengpt_PT
dc.publisherMDPIpt_PT
dc.relation.ispartofseriesMar. Drugs 2018, 16(7), 242pt_PT
dc.rightsopenAccesspt_PT
dc.subjectzoanthariapt_PT
dc.subjectTropical Eastern Pacificpt_PT
dc.subjectZoanthus pulchelluspt_PT
dc.subjectzoanthaminept_PT
dc.subjectinflammationpt_PT
dc.titleZoanthamine Alkaloids from the Zoantharian Zoanthus cf. pulchellus and Their Effects in Neuroinflammationpt_PT
dc.typeArtigo em Revista Científica Internacionalpt_PT
dc.contributor.uportoCentro Interdisciplinar de Investigação Marinha e Ambientalpt_PT
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