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Author(s): Leiro, V
Garcia, J
Tomás, H
Pêgo, AP
Title: The Present and the Future of Degradable Dendrimers and Derivatives in Theranostics
Publisher: American Chemical Society
Issue Date: 2015
Abstract: Interest in dendrimer-based nanomedicines has been growing recently, as it is possible to precisely manipulate the molecular weight, chemical composition, and surface functionality of dendrimers, tuning their properties according to the desired biomedical application. However, one important concern about dendrimer-based therapeutics remains-the nondegradability under physiological conditions of the most commonly used dendrimers. Therefore, biodegradable dendrimers represent an attractive class of nanomaterials, since they present advantages over conventional nondegradable dendrimers regarding the release of the loaded molecules and the prevention of bioaccumulation of synthetic materials and subsequent cytotoxicity. Here, we present an overview of the state-of-the-art of the design of biodegradable dendritic structures, with particular focus on the hurdles regarding the use of these as vectors of drugs and nucleic acids, as well as macromolecular contrast agents.
Subject: Animals
Biocompatible Materials/chemistry
Biocompatible Materials/metabolism
Contrast Media/chemistry
Contrast Media/metabolism
Drug Delivery Systems/methods
Gene Transfer Techniques
Magnetic Resonance Imaging/methods
Nucleic Acids/administration & dosage
Pharmaceutical Preparations/administration & dosage
Theranostic Nanomedicine/methods
Source: Bioconjugate Chemistry, vol. 26(7), p. 1182-1197
Related Information: info:eu-repo/grantAgreement/FCT/3599-PPCDT/112428/PT
Document Type: Artigo em Revista Científica Internacional
Rights: openAccess
Appears in Collections:I3S - Artigo em Revista Científica Internacional

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