Please use this identifier to cite or link to this item: https://hdl.handle.net/10216/120734
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dc.creatorLeiro, V
dc.creatorGarcia, J
dc.creatorTomás, H
dc.creatorPêgo, AP
dc.date.accessioned2019-06-25T12:08:39Z-
dc.date.available2019-06-25T12:08:39Z-
dc.date.issued2015
dc.identifier.issn1043-1802
dc.identifier.urihttps://hdl.handle.net/10216/120734-
dc.description.abstractInterest in dendrimer-based nanomedicines has been growing recently, as it is possible to precisely manipulate the molecular weight, chemical composition, and surface functionality of dendrimers, tuning their properties according to the desired biomedical application. However, one important concern about dendrimer-based therapeutics remains-the nondegradability under physiological conditions of the most commonly used dendrimers. Therefore, biodegradable dendrimers represent an attractive class of nanomaterials, since they present advantages over conventional nondegradable dendrimers regarding the release of the loaded molecules and the prevention of bioaccumulation of synthetic materials and subsequent cytotoxicity. Here, we present an overview of the state-of-the-art of the design of biodegradable dendritic structures, with particular focus on the hurdles regarding the use of these as vectors of drugs and nucleic acids, as well as macromolecular contrast agents.
dc.description.sponsorshipThe authors would like to acknowledge the FEDER funds through the Programa Operacional Factores de Competitividade − COMPETE and the Portuguese funds through FCT − Fundação para a Ciência e a Tecnologia (PTDC/CTM-NAN/112428/2009, PEst/SAU/LA0002/2013 and PEst-OE/QUI/UI0674/2013-2014) that supported this work. V. Leiro is supported by FCT (SFRH/BPD/69110/2010).
dc.language.isoeng
dc.publisherAmerican Chemical Society
dc.relationinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/112428/PT
dc.relationinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F69110%2F2010/PT
dc.relation.ispartofBioconjugate Chemistry, vol. 26(7), p. 1182-1197
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.subjectAnimals
dc.subjectBiocompatible Materials/chemistry
dc.subjectBiocompatible Materials/metabolism
dc.subjectContrast Media/chemistry
dc.subjectContrast Media/metabolism
dc.subjectDendrimers/chemistry
dc.subjectDendrimers/metabolism
dc.subjectDrug Delivery Systems/methods
dc.subjectGene Transfer Techniques
dc.subjectHumans
dc.subjectMagnetic Resonance Imaging/methods
dc.subjectNanostructures/chemistry
dc.subjectNucleic Acids/administration & dosage
dc.subjectPharmaceutical Preparations/administration & dosage
dc.subjectTheranostic Nanomedicine/methods
dc.titleThe Present and the Future of Degradable Dendrimers and Derivatives in Theranostics
dc.typeArtigo em Revista Científica Internacional
dc.contributor.uportoInstituto de Investigação e Inovação em Saúde
dc.identifier.doi10.1021/bc5006224
dc.relation.publisherversionhttps://pubs.acs.org/doi/10.1021/bc5006224
Appears in Collections:I3S - Artigo em Revista Científica Internacional

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