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Author(s): Ribeiro C.
Santos C.
Gonçalves V.
Ramos A.
Afonso C.
Tiritan M.E.
Title: Chiral drug analysis in forensic chemistry: An overview
Publisher: MDPI
Issue Date: 2018
Abstract: Many substances of forensic interest are chiral and available either as racemates or pure enantiomers. Application of chiral analysis in biological samples can be useful for the determination of legal or illicit drugs consumption or interpretation of unexpected toxicological effects. Chiral substances can also be found in environmental samples and revealed to be useful for determination of community drug usage (sewage epidemiology), identification of illicit drug manufacturing locations, illegal discharge of sewage and in environmental risk assessment. Thus, the purpose of this paper is to provide an overview of the application of chiral analysis in biological and environmental samples and their relevance in the forensic field. Most frequently analytical methods used to quantify the enantiomers are liquid and gas chromatography using both indirect, with enantiomerically pure derivatizing reagents, and direct methods recurring to chiral stationary phases. © 2018 by the authors.
Subject: drug
forensic science
gas chromatography
liquid chromatography
Chromatography, Gas
Chromatography, Liquid
Forensic Sciences
Pharmaceutical Preparations
Source: Molecules, vol. 23(2):262
Related Information: info:eu-repo/grantAgreement/FCT/5876/147268/PT
Document Type: Artigo em Revista Científica Internacional
Rights: openAccess
Appears in Collections:CIIMAR - Artigo em Revista Científica Internacional

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