Please use this identifier to cite or link to this item: https://hdl.handle.net/10216/120498
Author(s): Neves A.R.
Correia-da-Silva M.
Sousa E.
Pinto M.
Title: Strategies to overcome heparins’ low oral bioavailability
Publisher: MDPI
Issue Date: 2016
Abstract: Even after a century, heparin is still the most effective anticoagulant available with few side effects. The poor oral absorption of heparins triggered the search for strategies to achieve oral bioavailability since this route has evident advantages over parenteral administration. Several approaches emerged, such as conjugation of heparins with bile acids and lipids, formulation with penetration enhancers, and encapsulation of heparins in micro and nanoparticles. Some of these strategies appear to have potential as good delivery systems to overcome heparin’s low oral bioavailability. Nevertheless, none have reached the market yet. Overall, this review aims to provide insights regarding the oral bioavailability of heparin. © 2016 by the author; licensee MDPI, Basel, Switzerland.
Subject: ardeparin
arginine
chitosan
cholesterol
deoxycholic acid
dimethyl sulfoxide
docetaxel
enoxaparin
glycyrrhetinic acid
heparin
labrasol
lauric acid
low molecular weight heparin
palmitic acid
reviparin
tinzaparin
anticoagulation
cell permeabilization
cell viability
conjugation
controlled drug release
deep vein thrombosis
drug absorption
drug bioavailability
drug delivery system
drug distribution
drug efficacy
drug formulation
drug mechanism
drug metabolism
drug solubility
endocytosis
human
lipophilicity
malignant neoplastic disease
monotherapy
nanoencapsulation
nonhuman
phase 1 clinical trial (topic)
phase 3 clinical trial (topic)
randomized controlled trial (topic)
Review
tight junction
URI: https://hdl.handle.net/10216/120498
Source: Pharmaceuticals, vol. 9(3):37
Related Information: info:eu-repo/grantAgreement/FCT/5876/147268/PT
Document Type: Artigo em Revista Científica Internacional
Rights: openAccess
Appears in Collections:CIIMAR - Artigo em Revista Científica Internacional

Files in This Item:
File Description SizeFormat 
Neves AR_2016.pdf1.78 MBAdobe PDFThumbnail
View/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.