Utilize este identificador para referenciar este registo:
https://hdl.handle.net/10216/120498
Autor(es): | Neves A.R. Correia-da-Silva M. Sousa E. Pinto M. |
Título: | Strategies to overcome heparins’ low oral bioavailability |
Editor: | MDPI |
Data de publicação: | 2016 |
Resumo: | Even after a century, heparin is still the most effective anticoagulant available with few side effects. The poor oral absorption of heparins triggered the search for strategies to achieve oral bioavailability since this route has evident advantages over parenteral administration. Several approaches emerged, such as conjugation of heparins with bile acids and lipids, formulation with penetration enhancers, and encapsulation of heparins in micro and nanoparticles. Some of these strategies appear to have potential as good delivery systems to overcome heparin’s low oral bioavailability. Nevertheless, none have reached the market yet. Overall, this review aims to provide insights regarding the oral bioavailability of heparin. © 2016 by the author; licensee MDPI, Basel, Switzerland. |
Assunto: | ardeparin arginine chitosan cholesterol deoxycholic acid dimethyl sulfoxide docetaxel enoxaparin glycyrrhetinic acid heparin labrasol lauric acid low molecular weight heparin palmitic acid reviparin tinzaparin anticoagulation cell permeabilization cell viability conjugation controlled drug release deep vein thrombosis drug absorption drug bioavailability drug delivery system drug distribution drug efficacy drug formulation drug mechanism drug metabolism drug solubility endocytosis human lipophilicity malignant neoplastic disease monotherapy nanoencapsulation nonhuman phase 1 clinical trial (topic) phase 3 clinical trial (topic) randomized controlled trial (topic) Review tight junction |
URI: | https://hdl.handle.net/10216/120498 |
Fonte: | Pharmaceuticals, vol. 9(3):37 |
Informação Relacionada: | info:eu-repo/grantAgreement/FCT/5876/147268/PT |
Tipo de Documento: | Artigo em Revista Científica Internacional |
Condições de Acesso: | openAccess |
Aparece nas coleções: | CIIMAR - Artigo em Revista Científica Internacional |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Neves AR_2016.pdf | 1.78 MB | Adobe PDF | Ver/Abrir |
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