Please use this identifier to cite or link to this item: https://hdl.handle.net/10216/120476
Author(s): Kumla D.
Pereira J.A.
Dethoup T.
Gales L.
Freitas-Silva J.
Costa P.M.
Lee M.
Silva A.M.S.
Sekeroglu N.
Pinto M.M.M.
Kijjoa A.
Title: Chromone derivatives and other constituents from cultures of the marine sponge-associated fungus penicillium erubescens KUFA0220 and their antibacterial activity
Publisher: MDPI
Issue Date: 2018
Abstract: A previously unreported chromene derivative, 1-hydroxy-12-methoxycitromycin (1c), and four previously undescribed chromone derivatives, including pyanochromone (3b), spirofuranochromone (4), 7-hydroxy-6-methoxy-4-oxo-3-[(1E)-3-oxobut-1-en-1-yl]-4H-chromene-5-carboxylic acid (5), a pyranochromone dimer (6) were isolated, together with thirteen known compounds: β-sitostenone, ergosterol 5,8-endoperoxide, citromycin (1a), 12-methoxycitromycin (1b), myxotrichin D (1d), 12-methoxycitromycetin (1e), anhydrofulvic acid (2a), myxotrichin C (2b), penialidin D (2c), penialidin F (3a), SPF-3059-30 (7), GKK1032B (8) and secalonic acid A (9), from cultures of the marine sponge- associated fungus Penicillium erubescens KUFA0220. Compounds 1a-e, 2a, 3a, 4, 7-9, were tested for their antibacterial activity against Gram-positive and Gram-negative reference and multidrug-resistant strains isolated from the environment. Only 8 exhibited an in vitro growth inhibition of all Gram-positive bacteria whereas 9 showed growth inhibition of methicillin-resistant Staphyllococus aureus (MRSA). None of the compounds were active against Gram-negative bacteria tested. © 2018 MDPI. All Rights Reserved.
Subject: 1 hydroxy 12 methoxycitromycin
12 methoxycitromycetin
7 hydroxy 6 methoxy 4 oxo 3 [3 oxobut 1 en 1 yl] 4h chromene 5 carboxylic acid
anhydrofulvic acid
beta sitostenone
chromone derivative
citromycin
ergosterol 5,8 endoperoxide
gkk 1032 b
myxotrichin C
myxotrichin D
penialidin D
penialidin F
pyanochromone
pyranochromone dimer
secalonic acid A
spf 3059 30
spirofuranochromone
unclassified drug
antiinfective agent
chromone derivative
antibacterial activity
Article
bacterial growth
bacterial strain
controlled study
drug structure
Enterococcus faecium
fungal strain
fungus culture
growth inhibition
in vitro study
methicillin resistant Staphylococcus aureus
minimum bactericidal concentration
minimum inhibitory concentration
nonhuman
Penicillium
Penicillium erubescens
vancomycin resistant Enterococcus
animal
aquatic species
bacterium
chemistry
drug effect
fungus
Penicillium
sponge (Porifera)
Animals
Anti-Bacterial Agents
Aquatic Organisms
Bacteria
Chromones
Fungi
Penicillium
Porifera
URI: https://hdl.handle.net/10216/120476
Source: Marine Drugs, vol. 16(8): md16080289
Document Type: Artigo em Revista Científica Internacional
Rights: openAccess
Appears in Collections:CIIMAR - Artigo em Revista Científica Internacional

Files in This Item:
File Description SizeFormat 
Kumla D_2018.pdf2.04 MBAdobe PDFThumbnail
View/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.