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dc.creatorKumla D.
dc.creatorPereira J.A.
dc.creatorDethoup T.
dc.creatorGales L.
dc.creatorFreitas-Silva J.
dc.creatorCosta P.M.
dc.creatorLee M.
dc.creatorSilva A.M.S.
dc.creatorSekeroglu N.
dc.creatorPinto M.M.M.
dc.creatorKijjoa A.
dc.description.abstractA previously unreported chromene derivative, 1-hydroxy-12-methoxycitromycin (1c), and four previously undescribed chromone derivatives, including pyanochromone (3b), spirofuranochromone (4), 7-hydroxy-6-methoxy-4-oxo-3-[(1E)-3-oxobut-1-en-1-yl]-4H-chromene-5-carboxylic acid (5), a pyranochromone dimer (6) were isolated, together with thirteen known compounds: β-sitostenone, ergosterol 5,8-endoperoxide, citromycin (1a), 12-methoxycitromycin (1b), myxotrichin D (1d), 12-methoxycitromycetin (1e), anhydrofulvic acid (2a), myxotrichin C (2b), penialidin D (2c), penialidin F (3a), SPF-3059-30 (7), GKK1032B (8) and secalonic acid A (9), from cultures of the marine sponge- associated fungus Penicillium erubescens KUFA0220. Compounds 1a-e, 2a, 3a, 4, 7-9, were tested for their antibacterial activity against Gram-positive and Gram-negative reference and multidrug-resistant strains isolated from the environment. Only 8 exhibited an in vitro growth inhibition of all Gram-positive bacteria whereas 9 showed growth inhibition of methicillin-resistant Staphyllococus aureus (MRSA). None of the compounds were active against Gram-negative bacteria tested. © 2018 MDPI. All Rights Reserved.
dc.description.sponsorshipFunding: This research was funded by Fundação para a Ciências e Tecnologia (FCT) (grant number POCI-01-0145-FEDER-016790) and North Portugal Regional Operational Programme (NORTE 2020)(grant number NORTE-01-0145-FEDER-000035). Acknowledgments: This work was partially supported through national funds provided by FCT/MCTES-Foundation for Science and Technology from the Minister of Science, Technology and Higher Education (PIDDAC) and European Regional Development Fund (ERDF) through the COMPETE—Programa Operacional Factores de Competitividade (POFC) programme, under the project PTDC/MAR-BIO/4694/2014 (reference POCI-01-0145-FEDER-016790; Project 3599-Promover a Produção Científica e Desenvolvimento Tecnológico e a Constituição de Redes Temáticas (3599-PPCDT)) in the framework of the programme PT2020 as well as by the project INNOVMAR-Innovation and Sustainability in the Management and Exploitation of Marine Resources (reference NORTE-01-0145-FEDER-000035, within Research Line NOVELMAR), supported by North Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF). Decha Kumla thanks the Alfabet Project of the Erasmus Mundus for a PhD’s scholarship. We thank Júlia Bessa and Sara Cravo for technical support.
dc.relation.ispartofMarine Drugs, vol. 16(8): md16080289
dc.subject1 hydroxy 12 methoxycitromycin
dc.subject12 methoxycitromycetin
dc.subject7 hydroxy 6 methoxy 4 oxo 3 [3 oxobut 1 en 1 yl] 4h chromene 5 carboxylic acid
dc.subjectanhydrofulvic acid
dc.subjectbeta sitostenone
dc.subjectchromone derivative
dc.subjectergosterol 5,8 endoperoxide
dc.subjectgkk 1032 b
dc.subjectmyxotrichin C
dc.subjectmyxotrichin D
dc.subjectpenialidin D
dc.subjectpenialidin F
dc.subjectpyranochromone dimer
dc.subjectsecalonic acid A
dc.subjectspf 3059 30
dc.subjectunclassified drug
dc.subjectantiinfective agent
dc.subjectchromone derivative
dc.subjectantibacterial activity
dc.subjectbacterial growth
dc.subjectbacterial strain
dc.subjectcontrolled study
dc.subjectdrug structure
dc.subjectEnterococcus faecium
dc.subjectfungal strain
dc.subjectfungus culture
dc.subjectgrowth inhibition
dc.subjectin vitro study
dc.subjectmethicillin resistant Staphylococcus aureus
dc.subjectminimum bactericidal concentration
dc.subjectminimum inhibitory concentration
dc.subjectPenicillium erubescens
dc.subjectvancomycin resistant Enterococcus
dc.subjectaquatic species
dc.subjectdrug effect
dc.subjectsponge (Porifera)
dc.subjectAnti-Bacterial Agents
dc.subjectAquatic Organisms
dc.titleChromone derivatives and other constituents from cultures of the marine sponge-associated fungus penicillium erubescens KUFA0220 and their antibacterial activity
dc.typeArtigo em Revista Científica Internacional
dc.contributor.uportoCIIMAR - Centro Interdisciplinar de Investigação Marinha e Ambiental
Appears in Collections:CIIMAR - Artigo em Revista Científica Internacional

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