Please use this identifier to cite or link to this item:
https://hdl.handle.net/10216/120447
Author(s): | Silva B. Pereira J.A. Cravo S. Araújo A.M. Fernandes C. Pinto M.M.M. de Pinho P.G. Remião F. |
Title: | Multi-milligram resolution and determination of absolute configuration of pentedrone and methylone enantiomers |
Publisher: | Elsevier |
Issue Date: | 2018 |
Abstract: | The enantioresolution of pentedrone and methylone was carried out at a multi-milligram scale by liquid chromatography on a Chiralpak AS® stationary phase. The excellent enantioresolution using this column allowed to collect highly pure enantiomeric fractions, achieving enantiomeric ratios higher than 98%. An overall recovery of 72% was achieved for pentedrone enantiomers and 80% for methylone. Furthermore, the absolute configuration of the enantiomers of both cathinones was determined for the first time by electronic circular dichroism (ECD) spectroscopy, with the aid of theoretical calculations, as (+)‑(S) and (−)‑(R)-pentedrone, and (−)‑(S) and (+)‑(R)‑methylone. © 2018 Elsevier |
Subject: | Circular dichroism spectroscopy Dichroism Enantiomers Liquid chromatography Absolute configuration Cathinones Enantioresolution Methylone Pentedrone Stationary phase Drug products central stimulant agent methylone pentedrone unclassified drug alkanone methamphetamine methylamine methylone pentedrone analytic method Article chemical structure electronic circular dichroism elemental analysis enantiomer enantiomeric ratio enantioselectivity liquid chromatography mass fragmentography mass spectrometry nuclear magnetic resonance priority journal analogs and derivatives chemistry circular dichroism high performance liquid chromatography molecular model stereoisomerism Chromatography, High Pressure Liquid Circular Dichroism Methamphetamine Methylamines Models, Molecular Pentanones Stereoisomerism |
URI: | https://hdl.handle.net/10216/120447 |
Source: | Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, vol. 1100-1101, p. 158-164 |
Related Information: | info:eu-repo/grantAgreement/FCT/5876/147268/PT |
Document Type: | Artigo em Revista Científica Internacional |
Rights: | restrictedAccess |
Appears in Collections: | CIIMAR - Artigo em Revista Científica Internacional |
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