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  2. CIIMAR - Centro Interdisciplinar de Investigação Marinha e Ambiental
  3. CIIMAR - Artigo em Revista Científica Internacional
Please use this identifier to cite or link to this item: https://hdl.handle.net/10216/120447
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dc.creatorSilva B.
dc.creatorPereira J.A.
dc.creatorCravo S.
dc.creatorAraújo A.M.
dc.creatorFernandes C.
dc.creatorPinto M.M.M.
dc.creatorde Pinho P.G.
dc.creatorRemião F.
dc.date.accessioned2019-05-31T16:15:52Z-
dc.date.available2019-05-31T16:15:52Z-
dc.date.issued2018
dc.identifier.issn15700232
dc.identifier.urihttps://hdl.handle.net/10216/120447-
dc.description.abstractThe enantioresolution of pentedrone and methylone was carried out at a multi-milligram scale by liquid chromatography on a Chiralpak AS® stationary phase. The excellent enantioresolution using this column allowed to collect highly pure enantiomeric fractions, achieving enantiomeric ratios higher than 98%. An overall recovery of 72% was achieved for pentedrone enantiomers and 80% for methylone. Furthermore, the absolute configuration of the enantiomers of both cathinones was determined for the first time by electronic circular dichroism (ECD) spectroscopy, with the aid of theoretical calculations, as (+)‑(S) and (−)‑(R)-pentedrone, and (−)‑(S) and (+)‑(R)‑methylone. © 2018 Elsevier
dc.description.sponsorshipThis research was partially supported by the Strategic Funding UID/Multi/04423/2013 through national funds provided by FCT – Foundation for Science and Technology and European Regional Development Fund (ERDF), in the framework of the programme PT2020, and also with funding from PTDC/MAR-BIO/4694/2014 project. Bárbara Silva thanks the Universidade do Porto /FMUP through FSE-Fundo Social Europeu, NORTE2020 -Programa Operacional Regional do Norte, no âmbito da operação NORTE-08-5369-FSE-000011-Programas Doutorais for her PhD grant.
dc.language.isoeng
dc.publisherElsevier
dc.relationinfo:eu-repo/grantAgreement/FCT/5876/147268/PT
dc.relation.ispartofJournal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, vol. 1100-1101, p. 158-164
dc.rightsrestrictedAccess
dc.subjectCircular dichroism spectroscopy
dc.subjectDichroism
dc.subjectEnantiomers
dc.subjectLiquid chromatography
dc.subjectAbsolute configuration
dc.subjectCathinones
dc.subjectEnantioresolution
dc.subjectMethylone
dc.subjectPentedrone
dc.subjectStationary phase
dc.subjectDrug products
dc.subjectcentral stimulant agent
dc.subjectmethylone
dc.subjectpentedrone
dc.subjectunclassified drug
dc.subjectalkanone
dc.subjectmethamphetamine
dc.subjectmethylamine
dc.subjectmethylone
dc.subjectpentedrone
dc.subjectanalytic method
dc.subjectArticle
dc.subjectchemical structure
dc.subjectelectronic circular dichroism
dc.subjectelemental analysis
dc.subjectenantiomer
dc.subjectenantiomeric ratio
dc.subjectenantioselectivity
dc.subjectliquid chromatography
dc.subjectmass fragmentography
dc.subjectmass spectrometry
dc.subjectnuclear magnetic resonance
dc.subjectpriority journal
dc.subjectanalogs and derivatives
dc.subjectchemistry
dc.subjectcircular dichroism
dc.subjecthigh performance liquid chromatography
dc.subjectmolecular model
dc.subjectstereoisomerism
dc.subjectChromatography, High Pressure Liquid
dc.subjectCircular Dichroism
dc.subjectMethamphetamine
dc.subjectMethylamines
dc.subjectModels, Molecular
dc.subjectPentanones
dc.subjectStereoisomerism
dc.titleMulti-milligram resolution and determination of absolute configuration of pentedrone and methylone enantiomers
dc.typeArtigo em Revista Científica Internacional
dc.contributor.uportoCIIMAR - Centro Interdisciplinar de Investigação Marinha e Ambiental
dc.identifier.doi10.1016/j.jchromb.2018.10.002
dc.relation.publisherversionhttp://dx.doi.org/10.1016/j.jchromb.2018.10.002
Appears in Collections:CIIMAR - Artigo em Revista Científica Internacional

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