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Author(s): El-Demerdash A.
Tammam M.A.
Atanasov A.G.
Hooper J.N.A.
Al-Mourabit A.
Kijjoa A.
Title: Chemistry and biological activities of the marine sponges of the genera mycale (Arenochalina), Biemna and Clathria
Publisher: MDPI
Issue Date: 2018
Abstract: Over the past seven decades, particularly since the discovery of the first marine-derived nucleosides, spongothymidine and spongouridine, from the Caribbean sponge Cryptotethya crypta in the early 1950s, marine natural products have emerged as unique, renewable and yet under-investigated pools for discovery of new drug leads with distinct structural features, and myriad interesting biological activities. Marine sponges are the most primitive and simplest multicellular animals, with approximately 8900 known described species, although more than 15,000 species are thought to exist worldwide today. These marine organisms potentially represent the richest pipeline for novel drug leads. Mycale (Arenochalina) and Clathria are recognized marine sponge genera belonging to the order Poecilosclerida, whereas Biemna was more recently reclassified, based on molecular genetics, as a new order Biemnida. Together, these sponge genera contribute to the production of physiologically active molecular entities with diverse structural features and a wide range of medicinal and therapeutic potentialities. In this review, we provide a comprehensive insight and up-to-date literature survey over the period of 1976–2018, focusing on the chemistry of the isolated compounds from members of these three genera, as well as their biological and pharmacological activities, whenever available. © 2018 by the authors.
Subject: 8,9 dihydro 11 hydroxyascididemin
araiosamine A
araiosamine B
araiosamine C
araiosamine D
batzelladine derivative
clathrynamide A
clathrynamide B
clathrynamide C
crambescidin derivative
ecionine A
guanidine derivative
mirabilin A
mirabilin B
mirabilin C
mirabilin D
mirabilin E
mirabilin F
mycalazal derivative
mycalazol derivative
n hydroxymethylisocystodamine
natural product
neolabuaninen A
netamine M
pteridine derivative
ptilocaulin derivative
unclassified drug
unindexed drug
biological product
antibacterial activity
antifungal activity
antineoplastic activity
antiviral activity
biological activity
chemical analysis
drug classification
drug cytotoxicity
drug isolation
drug research
drug structure
mass fragmentography
mass spectrometry
nuclear magnetic resonance spectroscopy
physical chemistry
sponge (Porifera)
aquatic species
chemical structure
isolation and purification
sponge (Porifera)
Aquatic Organisms
Biological Products
Molecular Structure
Source: Marine Drugs, vol. 16(6): 214;
Document Type: Artigo em Revista Científica Internacional
Rights: openAccess
Appears in Collections:CIIMAR - Artigo em Revista Científica Internacional

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