Please use this identifier to cite or link to this item:
https://hdl.handle.net/10216/120419
Author(s): | El-Demerdash A. Tammam M.A. Atanasov A.G. Hooper J.N.A. Al-Mourabit A. Kijjoa A. |
Title: | Chemistry and biological activities of the marine sponges of the genera mycale (Arenochalina), Biemna and Clathria |
Publisher: | MDPI |
Issue Date: | 2018 |
Abstract: | Over the past seven decades, particularly since the discovery of the first marine-derived nucleosides, spongothymidine and spongouridine, from the Caribbean sponge Cryptotethya crypta in the early 1950s, marine natural products have emerged as unique, renewable and yet under-investigated pools for discovery of new drug leads with distinct structural features, and myriad interesting biological activities. Marine sponges are the most primitive and simplest multicellular animals, with approximately 8900 known described species, although more than 15,000 species are thought to exist worldwide today. These marine organisms potentially represent the richest pipeline for novel drug leads. Mycale (Arenochalina) and Clathria are recognized marine sponge genera belonging to the order Poecilosclerida, whereas Biemna was more recently reclassified, based on molecular genetics, as a new order Biemnida. Together, these sponge genera contribute to the production of physiologically active molecular entities with diverse structural features and a wide range of medicinal and therapeutic potentialities. In this review, we provide a comprehensive insight and up-to-date literature survey over the period of 1976–2018, focusing on the chemistry of the isolated compounds from members of these three genera, as well as their biological and pharmacological activities, whenever available. © 2018 by the authors. |
Subject: | 8,9 dihydro 11 hydroxyascididemin alkaloid araiosamine A araiosamine B araiosamine C araiosamine D batzelladine derivative biemnadin clathrynamide A clathrynamide B clathrynamide C crambescidin derivative cyclopeptide ecionine A guanidine derivative mirabilin A mirabilin B mirabilin C mirabilin D mirabilin E mirabilin F mycalazal derivative mycalazol derivative n hydroxymethylisocystodamine natural product neolabuaninen A netamine M pteridine derivative ptilocaulin derivative unclassified drug unindexed drug biological product antibacterial activity antifungal activity antineoplastic activity antiviral activity Biemna biological activity chemical analysis Clathria drug classification drug cytotoxicity drug isolation drug research drug structure human mass fragmentography mass spectrometry Mycale nonhuman nuclear magnetic resonance spectroscopy physical chemistry Review sponge (Porifera) animal aquatic species chemical structure chemistry isolation and purification metabolism sponge (Porifera) Animals Aquatic Organisms Biological Products Molecular Structure Porifera |
URI: | https://hdl.handle.net/10216/120419 |
Source: | Marine Drugs, vol. 16(6): 214; |
Document Type: | Artigo em Revista Científica Internacional |
Rights: | openAccess |
Appears in Collections: | CIIMAR - Artigo em Revista Científica Internacional |
Files in This Item:
File | Description | Size | Format | |
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El-Demerdash A_2018.pdf | 8.81 MB | Adobe PDF | View/Open |
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