Please use this identifier to cite or link to this item: https://hdl.handle.net/10216/120401
Author(s): Nogueira A.F.
Pereira J.L.
Antunes S.C.
Gonçalves F.J.M.
Nunes B.
Title: Effects of zinc pyrithione on biochemical parameters of the freshwater Asian clam Corbicula fluminea
Publisher: Elsevier
Issue Date: 2018
Abstract: Zinc pyrithione (ZnPT) is an organometallic biocide with bactericide, algaecide, and fungicide activity. Considering this biological activity, ZnPT has been used in anti-fouling paints, and also in human therapeutics and cosmetics, in shampoos to treat dandruff and seborrhoea. Despite its potential uses and consequent presence in the aquatic environment, the ecotoxicological effects of ZnPT are poorly understood. This work aims to characterise the effects of ZnPT in biochemical parameters of the Asian clam, one of the most invasive bivalves known for its biofouling action in hydro-dependent industries, using a classical (LC50 determination) and a biomarker-based approach (quantification of the activities of catalase, GSTs, and acetylcholinesterase, and also the muscle glycogen content). The here determined LC50-96 h for zinc pyrithione was 2.17 mg/L. ZnPT caused significant increases in the activity of catalase and of cholinesterases. These findings evidence the pro-oxidative effects caused by the metabolism of ZnPT. Despite the absence of clear effects, it is important to stress that the presence of ZnPT in the wild is usually accompanied by other pyrithiones, whose co-existence can contribute to the exertion of considerable toxic effects. © 2018 Elsevier
Subject: acetylcholinesterase
catalase
glutathione synthase
pyrithione zinc
acetylcholinesterase
biological marker
catalase
disinfectant agent
fresh water
glutathione transferase
glycogen
organometallic compound
pyridine derivative
pyrithione zinc
antifouling
biomarker
bivalve
dose-response relationship
invasive species
oxidative stress
pesticide
Article
biochemical analysis
biofouling
Corbicula
Corbicula fluminea
glycogen muscle level
LC50
metabolism
nonhuman
animal
Corbicula
drug effect
enzymology
toxicity
water pollutant
Bivalvia
Corbicula fluminea
Acetylcholinesterase
Animals
Biofouling
Biomarkers
Catalase
Corbicula
Disinfectants
Fresh Water
Glutathione Transferase
Glycogen
Organometallic Compounds
Pyridines
Water Pollutants, Chemical
URI: https://hdl.handle.net/10216/120401
Source: Aquatic Toxicology, vol. 204, p. 100-106
Document Type: Artigo em Revista Científica Internacional
Rights: restrictedAccess
Appears in Collections:CIIMAR - Artigo em Revista Científica Internacional

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