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https://hdl.handle.net/10216/120401
Autor(es): | Nogueira A.F. Pereira J.L. Antunes S.C. Gonçalves F.J.M. Nunes B. |
Título: | Effects of zinc pyrithione on biochemical parameters of the freshwater Asian clam Corbicula fluminea |
Editor: | Elsevier |
Data de publicação: | 2018 |
Resumo: | Zinc pyrithione (ZnPT) is an organometallic biocide with bactericide, algaecide, and fungicide activity. Considering this biological activity, ZnPT has been used in anti-fouling paints, and also in human therapeutics and cosmetics, in shampoos to treat dandruff and seborrhoea. Despite its potential uses and consequent presence in the aquatic environment, the ecotoxicological effects of ZnPT are poorly understood. This work aims to characterise the effects of ZnPT in biochemical parameters of the Asian clam, one of the most invasive bivalves known for its biofouling action in hydro-dependent industries, using a classical (LC50 determination) and a biomarker-based approach (quantification of the activities of catalase, GSTs, and acetylcholinesterase, and also the muscle glycogen content). The here determined LC50-96 h for zinc pyrithione was 2.17 mg/L. ZnPT caused significant increases in the activity of catalase and of cholinesterases. These findings evidence the pro-oxidative effects caused by the metabolism of ZnPT. Despite the absence of clear effects, it is important to stress that the presence of ZnPT in the wild is usually accompanied by other pyrithiones, whose co-existence can contribute to the exertion of considerable toxic effects. © 2018 Elsevier |
Assunto: | acetylcholinesterase catalase glutathione synthase pyrithione zinc acetylcholinesterase biological marker catalase disinfectant agent fresh water glutathione transferase glycogen organometallic compound pyridine derivative pyrithione zinc antifouling biomarker bivalve dose-response relationship invasive species oxidative stress pesticide Article biochemical analysis biofouling Corbicula Corbicula fluminea glycogen muscle level LC50 metabolism nonhuman animal Corbicula drug effect enzymology toxicity water pollutant Bivalvia Corbicula fluminea Acetylcholinesterase Animals Biofouling Biomarkers Catalase Corbicula Disinfectants Fresh Water Glutathione Transferase Glycogen Organometallic Compounds Pyridines Water Pollutants, Chemical |
URI: | https://hdl.handle.net/10216/120401 |
Fonte: | Aquatic Toxicology, vol. 204, p. 100-106 |
Tipo de Documento: | Artigo em Revista Científica Internacional |
Condições de Acesso: | restrictedAccess |
Aparece nas coleções: | CIIMAR - Artigo em Revista Científica Internacional |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Nogueira AF_2018.pdf Restricted Access | 329.38 kB | Adobe PDF | Request a copy |
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