Please use this identifier to cite or link to this item: https://hdl.handle.net/10216/120366
Author(s): Lopes-Marques M.
Machado A.M.
Ruivo R.
Fonseca E.
Carvalho E.
Castro L.F.C.
Title: Expansion, retention and loss in the Acyl-CoA synthetase “Bubblegum” (Acsbg) gene family in vertebrate history
Publisher: Elsevier
Issue Date: 2018
Abstract: Fatty acids (FAs) constitute a considerable fraction of all lipid molecules with a fundamental role in numerous physiological processes. In animals, the majority of complex lipid molecules are derived from the transformation of FAs through several biochemical pathways. Yet, for FAs to enroll in these pathways they require an activation step. FA activation is catalyzed by the rate limiting action of Acyl-CoA synthases. Several Acyl-CoA enzyme families have been previously described and classified according to the chain length of FAs they process. Here, we address the evolutionary history of the ACSBG gene family which activates, FAs with >16 carbons. Currently, two different ACSBG gene families, ACSBG1 and ACSBG2, are recognized in vertebrates. We provide evidence that a wider and unequal ACSBG gene repertoire is present in vertebrate lineages. We identify a novel ACSBG-like gene lineage which occurs specifically in amphibians, ray finned fishes, coelacanths and cartilaginous fishes named ACSBG3. Also, we show that the ACSBG2 gene lineage duplicated in the Theria ancestor. Our findings, thus offer a far richer understanding on FA activation in vertebrates and provide key insights into the relevance of comparative and functional analysis to perceive physiological differences, namely those related with lipid metabolic pathways. © 2018 Elsevier
Subject: ACSBG1 gene
ACSBG2 gene
ACSBG3 gene
Amphibia
Article
chondrichthyan
coelacanth
controlled study
data mining
evolutionary homology
gene
gene activation
gene duplication
gene expression
holostei
multigene family
nonhuman
phylogeny
priority journal
RNA sequence
teleost
therian
vertebrate
animal
chromosomal mapping
evolution
fish
gene duplication
genetics
metabolism
physiology
sequence alignment
acyl coenzyme A
coenzyme A ligase
fatty acid
long-chain-fatty-acid-CoA ligase
Acyl Coenzyme A
Animals
Biological Evolution
Chromosome Mapping
Coenzyme A Ligases
Fatty Acids
Fishes
Gene Duplication
Metabolic Networks and Pathways
Phylogeny
Sequence Alignment
Vertebrates
URI: https://hdl.handle.net/10216/120366
Source: Gene, vol. 664, p. 111-118
Document Type: Artigo em Revista Científica Internacional
Rights: restrictedAccess
Appears in Collections:CIIMAR - Artigo em Revista Científica Internacional

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