Please use this identifier to cite or link to this item:
https://hdl.handle.net/10216/120366
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Lopes-Marques M. | |
dc.creator | Machado A.M. | |
dc.creator | Ruivo R. | |
dc.creator | Fonseca E. | |
dc.creator | Carvalho E. | |
dc.creator | Castro L.F.C. | |
dc.date.accessioned | 2019-05-31T16:15:06Z | - |
dc.date.available | 2019-05-31T16:15:06Z | - |
dc.date.issued | 2018 | |
dc.identifier.issn | 3781119 | |
dc.identifier.uri | https://hdl.handle.net/10216/120366 | - |
dc.description.abstract | Fatty acids (FAs) constitute a considerable fraction of all lipid molecules with a fundamental role in numerous physiological processes. In animals, the majority of complex lipid molecules are derived from the transformation of FAs through several biochemical pathways. Yet, for FAs to enroll in these pathways they require an activation step. FA activation is catalyzed by the rate limiting action of Acyl-CoA synthases. Several Acyl-CoA enzyme families have been previously described and classified according to the chain length of FAs they process. Here, we address the evolutionary history of the ACSBG gene family which activates, FAs with >16 carbons. Currently, two different ACSBG gene families, ACSBG1 and ACSBG2, are recognized in vertebrates. We provide evidence that a wider and unequal ACSBG gene repertoire is present in vertebrate lineages. We identify a novel ACSBG-like gene lineage which occurs specifically in amphibians, ray finned fishes, coelacanths and cartilaginous fishes named ACSBG3. Also, we show that the ACSBG2 gene lineage duplicated in the Theria ancestor. Our findings, thus offer a far richer understanding on FA activation in vertebrates and provide key insights into the relevance of comparative and functional analysis to perceive physiological differences, namely those related with lipid metabolic pathways. © 2018 Elsevier | |
dc.description.sponsorship | This work was supported by Project INNOVMAR—Innovation and Sustainability in the Management and Exploitation of Marine Resources (reference NORTE-01-0145-FEDER-000035 , within Research Line NOVELMAR/INSEAFOOD/ECOSERVICES), supported by North Portugal Regional Operational Programme ( NORTE 2020 ), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF). We acknowledge Fundação para a Ciência e a Tecnologia for the support to EF (SFRH/BD/79305/2011). | |
dc.language.iso | eng | |
dc.publisher | Elsevier | |
dc.relation.ispartof | Gene, vol. 664, p. 111-118 | |
dc.rights | restrictedAccess | |
dc.subject | ACSBG1 gene | |
dc.subject | ACSBG2 gene | |
dc.subject | ACSBG3 gene | |
dc.subject | Amphibia | |
dc.subject | Article | |
dc.subject | chondrichthyan | |
dc.subject | coelacanth | |
dc.subject | controlled study | |
dc.subject | data mining | |
dc.subject | evolutionary homology | |
dc.subject | gene | |
dc.subject | gene activation | |
dc.subject | gene duplication | |
dc.subject | gene expression | |
dc.subject | holostei | |
dc.subject | multigene family | |
dc.subject | nonhuman | |
dc.subject | phylogeny | |
dc.subject | priority journal | |
dc.subject | RNA sequence | |
dc.subject | teleost | |
dc.subject | therian | |
dc.subject | vertebrate | |
dc.subject | animal | |
dc.subject | chromosomal mapping | |
dc.subject | evolution | |
dc.subject | fish | |
dc.subject | gene duplication | |
dc.subject | genetics | |
dc.subject | metabolism | |
dc.subject | physiology | |
dc.subject | sequence alignment | |
dc.subject | acyl coenzyme A | |
dc.subject | coenzyme A ligase | |
dc.subject | fatty acid | |
dc.subject | long-chain-fatty-acid-CoA ligase | |
dc.subject | Acyl Coenzyme A | |
dc.subject | Animals | |
dc.subject | Biological Evolution | |
dc.subject | Chromosome Mapping | |
dc.subject | Coenzyme A Ligases | |
dc.subject | Fatty Acids | |
dc.subject | Fishes | |
dc.subject | Gene Duplication | |
dc.subject | Metabolic Networks and Pathways | |
dc.subject | Phylogeny | |
dc.subject | Sequence Alignment | |
dc.subject | Vertebrates | |
dc.title | Expansion, retention and loss in the Acyl-CoA synthetase “Bubblegum” (Acsbg) gene family in vertebrate history | |
dc.type | Artigo em Revista Científica Internacional | |
dc.contributor.uporto | CIIMAR - Centro Interdisciplinar de Investigação Marinha e Ambiental | |
dc.identifier.doi | 10.1016/j.gene.2018.04.058 | |
dc.relation.publisherversion | http://dx.doi.org/10.1016/j.gene.2018.04.058 | |
Appears in Collections: | CIIMAR - Artigo em Revista Científica Internacional |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Lopes-Marques M_2018.pdf Restricted Access | 3.68 MB | Adobe PDF | Request a copy |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.